Journal of Medicinal Chemistry

Current research reports and chronological list of recent articles.


The international scientific Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

The publisher is the American Chemical Society, ACS. The copyright and publishing rights of specialized products listed below are in this publishing house. This is also responsible for the content shown.

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Additional research articles see Current Chemistry Research Articles. Magazines with similar content (medicinal chemistry):

 - Bioorganic and Medicinal Chemistry Letters,

 - European Journal of Medicinal Chemistry.

 - Journal of Enzyme Inhibition and Medicinal Chemistry,

 - Medicinal Chemistry Research,



Journal of Medicinal Chemistry - Abstracts



Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01647

Datum: 10.02.2016


Robenidine Analogues as Gram-Positive Antibacterial Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01797

Datum: 10.02.2016


Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01485

Datum: 09.02.2016


Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01586

Datum: 09.02.2016


Discovery of the First Environment-Sensitive Near-Infrared (NIR) Fluorogenic Ligand for α1-Adrenergic Receptors Imaging in Vivo

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01843

Datum: 09.02.2016


Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01464

Datum: 08.02.2016


Role of Molecular Dynamics and Related Methods in Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01684

Datum: 08.02.2016


Synthesis and Pharmacological Evaluation of Novel Adenine–Hydrogen Sulfide Slow Release Hybrids Designed as Multitarget Cardioprotective Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01223

Datum: 08.02.2016


2,6-Di(arylamino)-3-fluoropyridine Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01336

Datum: 08.02.2016


Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01723

Datum: 08.02.2016


Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01641

Datum: 08.02.2016


The Medicinal Chemistry of Dengue Virus

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01653

Datum: 05.02.2016


Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01618

Datum: 05.02.2016


Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01331

Datum: 05.02.2016


Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01654

Datum: 05.02.2016


Designed Glycopeptidomimetics Disrupt Protein–Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01629

Datum: 04.02.2016


Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01029

Datum: 04.02.2016


Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01882

Datum: 04.02.2016


Synthesis and in Vitro Screening of New Series of 2,6-Dipeptidyl-anthraquinones: Influence of Side Chain Length on HIV-1 Nucleocapsid Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01494

Datum: 03.02.2016


Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01430

Datum: 03.02.2016


Development of a Novel Nonpeptidic 18F-Labeled Radiotracer for in Vivo Imaging of Oxytocin Receptors with Positron Emission Tomography

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01080

Datum: 03.02.2016


Computational Exploration of Molecular Scaffolds in Medicinal Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01746

Datum: 03.02.2016


From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure–Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01439

Datum: 03.02.2016


Characterization of Multisubstituted Corticotropin Releasing Factor (CRF) Peptide Antagonists (Astressins)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00926

Datum: 03.02.2016


Enhanced Sphingomyelinase Activity Contributes to the Apoptotic Capacity of Electronegative Low-Density Lipoprotein

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01534

Datum: 02.02.2016


Recent Progress in Histone Demethylase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01758

Datum: 02.02.2016


Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01751

Datum: 02.02.2016


Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01402

Datum: 01.02.2016


Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00752

Datum: 01.02.2016


Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01961

Datum: 01.02.2016


The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01696

Datum: 29.01.2016


Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01772

Datum: 29.01.2016


Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01910

Datum: 29.01.2016


Epigenetics: Novel Therapeutics Targeting Epigenetics

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00098

Datum: 29.01.2016


Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[d-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01899

Datum: 29.01.2016


Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor–Nuclear Receptor Related 1 Protein Dimer Activation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01702

Datum: 28.01.2016


Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01633

Datum: 28.01.2016


Understanding the Complexity of Epigenetic Target Space

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01507

Datum: 28.01.2016


Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01599

Datum: 28.01.2016


Structure–Activity Relationship Study of Rakicidins: Overcoming Chronic Myeloid Leukemia Resistance to Imatinib with 4-Methylester-Rakicidin A

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01841

Datum: 27.01.2016


Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01593

Datum: 27.01.2016


The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01501

Datum: 27.01.2016


New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01333

Datum: 27.01.2016


Novel Water-Soluble Amphotericin B-PEG Conjugates with Low Toxicity and Potent in Vivo Efficacy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01862

Datum: 27.01.2016


Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01741

Datum: 27.01.2016


Novobiocin Analogues That Inhibit the MAPK Pathway

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01354

Datum: 27.01.2016


Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01752

Datum: 27.01.2016


99mTc-Cyclopentadienyl Tricarbonyl Chelate-Labeled Compounds as Selective Sigma-2 Receptor Ligands for Tumor Imaging

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01378

Datum: 26.01.2016


Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01559

Datum: 26.01.2016


Indole Based Weapons to Fight Antibiotic Resistance: A Structure–Activity Relationship Study

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01219

Datum: 26.01.2016


Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein–Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01305

Datum: 25.01.2016


Correction to Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00036

Datum: 25.01.2016


Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01503

Datum: 25.01.2016


Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01550

Datum: 22.01.2016


Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure–Activity Relationships of Novel 1-(Imidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one Derivatives

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01704

Datum: 22.01.2016


Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01697

Datum: 22.01.2016


Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01512

Datum: 22.01.2016


Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01685

Datum: 21.01.2016


The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01483

Datum: 20.01.2016


A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01532

Datum: 20.01.2016


Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure–Function Perspective

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01281

Datum: 19.01.2016


Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01538

Datum: 15.01.2016


Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01537

Datum: 15.01.2016


4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01267

Datum: 14.01.2016


Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01719

Datum: 13.01.2016


Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01511

Datum: 12.01.2016


Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01643

Datum: 12.01.2016


Interactive and Versatile Navigation of Structural Databases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01756

Datum: 08.01.2016


KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01502

Datum: 07.01.2016


8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01635

Datum: 07.01.2016


Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure–Activity Relationship Study

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01517

Datum: 07.01.2016


Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01632

Datum: 07.01.2016


Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01209

Datum: 07.01.2016


Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01708

Datum: 06.01.2016


1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01117

Datum: 05.01.2016


Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01323

Datum: 04.01.2016


Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01527

Datum: 23.12.2015


Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01493

Datum: 22.12.2015


Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K+ Channel 1). A Novel Therapeutic Target?

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00671

Datum: 14.12.2015


Protein-Observed Fluorine NMR: A Bioorthogonal Approach for Small Molecule Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01447

Datum: 14.12.2015


3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01296

Datum: 14.12.2015


Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01409

Datum: 01.12.2015


Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01514

Datum: 01.12.2015


Use of Photosensitizers in Semisolid Formulations for Microbial Photodynamic Inactivation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01129

Datum: 01.12.2015


Progress in the Development of Small Molecule Therapeutics for the Treatment of Neuronal Ceroid Lipofuscinoses (NCLs)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01020

Datum: 24.11.2015


AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01273

Datum: 20.11.2015


Monitoring the Progression of Structure–Activity Relationship Information during Lead Optimization

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01428

Datum: 16.11.2015


G Protein-Coupled Receptor 119 (GPR119) Agonists for the Treatment of Diabetes: Recent Progress and Prevailing Challenges

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01198

Datum: 09.11.2015


Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01201

Datum: 09.11.2015


Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trials

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01457

Datum: 09.11.2015


Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00497

Datum: 05.11.2015


Small Molecule CXCR3 Antagonists

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01337

Datum: 04.11.2015


How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01286

Datum: 30.10.2015


Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00683

Datum: 30.10.2015


C-Nucleosides To Be Revisited

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01157

Datum: 29.10.2015


Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01009

Datum: 27.10.2015


Computational Tools To Model Halogen Bonds in Medicinal Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00997

Datum: 21.10.2015


Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01342

Datum: 13.10.2015


Inhibiting the Inflammasome: A Chemical Perspective

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01091

Datum: 12.10.2015


New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01135

Datum: 01.10.2015


Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00828

Datum: 25.09.2015


Framing Neuro-Glia Coupling in Antiepileptic Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00331

Datum: 24.09.2015


Structure-Based Inhibitor Design for Evaluation of a CYP3A4 Pharmacophore Model

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01146

Datum: 24.09.2015


OpenGrowth: An Automated and Rational Algorithm for Finding New Protein Ligands

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00886

Datum: 23.09.2015


Tactical Approaches to Interconverting GPCR Agonists and Antagonists

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00982

Datum: 21.09.2015


Quantifying, Visualizing, and Monitoring Lead Optimization

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00948

Datum: 21.08.2015


Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01011

Datum: 20.08.2015


Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00171

Datum: 15.07.2015


Fragment-Based Design of Selective Nanomolar Ligands of the CREBBP Bromodomain

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00172

Datum: 15.07.2015


DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00150

Datum: 10.07.2015


Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00405

Datum: 06.07.2015


Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00458

Datum: 20.05.2015


Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00256

Datum: 30.04.2015


Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00209

Datum: 06.04.2015






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