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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



Activation of the ?-Aminobutyric Acid Type B (GABAB) Receptor by Agonists and Positive Allosteric Modulators

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/jm5018913

Posted on 24 April 2015 | 8:07 pm


Discovery of Potent Indenoisoquinoline Topoisomerase I Poisons Lacking the 3-Nitro Toxicophore

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00303

Posted on 24 April 2015 | 7:48 pm


HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00188

Posted on 24 April 2015 | 7:47 pm


6-Substituted Sulfocoumarins Are Selective Carbonic Anhdydrase IX and XII Inhibitors with Significant Cytotoxicity against Colorectal Cancer Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00523

Posted on 23 April 2015 | 5:11 pm


Correction to Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00591

Posted on 22 April 2015 | 9:47 pm


Structure–Activity Relationship in a Purine-Scaffold Compound Series with Selectivity for the Endoplasmic Reticulum Hsp90 Paralog Grp94

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00197

Posted on 22 April 2015 | 9:00 pm


pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00104

Posted on 22 April 2015 | 2:56 pm


ent-Kaurane Diterpenoids from Chinese Liverworts and Their Antitumor Activities through Michael Addition As Detected in Situ by a Fluorescence Probe

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00208

Posted on 21 April 2015 | 3:45 pm


A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00012

Posted on 20 April 2015 | 4:55 pm


Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00413

Posted on 20 April 2015 | 12:51 pm


Structure-Related Mode-of-Action Differences of Anticancer Organoruthenium Complexes with ?-Diketonates

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00288

Posted on 17 April 2015 | 5:48 pm


Discovery of Tricyclic Indoles That Potently Inhibit Mcl-1 Using Fragment-Based Methods and Structure-Based Design

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501984f

Posted on 17 April 2015 | 5:48 pm


Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00166

Posted on 16 April 2015 | 3:48 pm


Progress Toward the Development of Noscapine and Derivatives as Anticancer Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501180v

Posted on 16 April 2015 | 1:59 pm


Identification of Novel ROS Inducers: Quinone Derivatives Tethered to Long Hydrocarbon Chains

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501846y

Posted on 15 April 2015 | 1:56 pm


Poly(amidoamine) Dendrimers with Carbonic Anhydrase Inhibitory Activity and Antiglaucoma Action

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00383

Posted on 15 April 2015 | 1:39 pm


Peroxisome Proliferator-Activated Receptor ? (PPAR?) and Ligand Choreography: Newcomers Take the Stage

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501155f

Posted on 9 April 2015 | 4:30 pm


Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00209

Posted on 6 April 2015 | 2:30 pm


Volume of Distribution in Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00201

Posted on 1 April 2015 | 9:12 pm


Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501512b

Posted on 31 March 2015 | 3:31 pm


Clostridium difficile Drug Pipeline: Challenges in Discovery and Development of New Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5016846

Posted on 30 March 2015 | 8:15 pm


Discovery of a Cyclic Boronic Acid ?-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00127

Posted on 17 March 2015 | 9:09 pm


Fighting Malaria: Structure-Guided Discovery of Nonpeptidomimetic Plasmepsin Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5014133

Posted on 17 March 2015 | 2:02 pm


Origins of the Quinolone Class of Antibacterials: An Expanded “Discovery Story”

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501881c

Posted on 12 March 2015 | 8:02 pm


The Hippo Pathway and YAP/TAZ–TEAD Protein–Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501615v

Posted on 11 March 2015 | 7:46 pm


A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501853m

Posted on 3 March 2015 | 1:48 pm


Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5017544

Posted on 25 February 2015 | 6:51 pm


Synthetic Nucleic Acid Delivery Systems: Present and Perspectives

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500330k

Posted on 20 February 2015 | 7:04 pm


Bronchodilating Drugs for Chronic Obstructive Pulmonary Disease: Current Status and Future Trends

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5013227

Posted on 9 February 2015 | 4:58 pm


Progress in Discovery of KIF5B-RET Kinase Inhibitors for the Treatment of Non-Small-Cell Lung Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501464c

Posted on 4 February 2015 | 6:43 pm





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Chronological list of recent articles on Chemistry, Medicinal Chemistry, Journal of Medicinal Chemistry.
Update:
28.09.2013


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