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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500147k

Posted on 18 April 2014 | 3:22 pm


Indirubin Core Structure of Glycogen Synthase Kinase-3 Inhibitors as Novel Chemotype for Intervention with 5-Lipoxygenase

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401740w

Posted on 17 April 2014 | 7:08 pm


Motor Neuron Disease: A Chemical Perspective

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5001584

Posted on 17 April 2014 | 3:27 pm


New Potent Antibacterial Oxazolidinone (MRX-I) with an Improved Class Safety Profile

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401931e

Posted on 16 April 2014 | 7:12 pm


Matched Molecular Pair Analysis: Significance and the Impact of Experimental Uncertainty

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500317a

Posted on 16 April 2014 | 7:12 pm


Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500175z

Posted on 15 April 2014 | 10:04 pm


Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500176w

Posted on 15 April 2014 | 7:26 pm


Bis-alkylamine Indolo[3,2-b]quinolines as Hemozoin Ligands: Implications for Antimalarial Cytostatic and Cytocidal Activities

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500075d

Posted on 15 April 2014 | 4:39 pm


Development of Pyrazolone and Isoxazol-5-one Cambinol Analogues as Sirtuin Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4018064

Posted on 15 April 2014 | 4:38 pm


Identification and Characterization of Small Molecule Modulators of the Epstein–Barr Virus-Induced Gene 2 (EBI2) Receptor

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4019355

Posted on 15 April 2014 | 2:42 pm


Discovery of the First N-Hydroxycinnamamide-Based Histone Deacetylase 1/3 Dual Inhibitors with Potent Oral Antitumor Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401877m

Posted on 15 April 2014 | 12:20 pm


Far-Red Light Activatable, Multifunctional Prodrug for Fluorescence Optical Imaging and Combinational Treatment

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5000722

Posted on 14 April 2014 | 8:49 pm


Cyclic Secondary Sulfonamides: Unusually Good Inhibitors of Cancer-Related Carbonic Anhydrase Enzymes

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500255y

Posted on 11 April 2014 | 4:45 pm


Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500342d

Posted on 11 April 2014 | 3:54 pm


Discovery, Optimization, and Characterization of Novel D2 Dopamine Receptor Selective Antagonists

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500126s

Posted on 10 April 2014 | 8:22 pm


Discovery of Selective 4-Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500155b

Posted on 9 April 2014 | 8:38 pm


Thienoquinolines as Novel Disruptors of the PKC?/RACK2 Protein–Protein Interaction

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401605c

Posted on 8 April 2014 | 9:33 pm


Pharmacophoric Modifications Lead to Superpotent ?v?3 Integrin Ligands with Suppressed ?5?1 Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500092w

Posted on 8 April 2014 | 7:59 pm


Allosteric Inhibition of Human Factor XIa: Discovery of Monosulfated Benzofurans as a Class of Promising Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5002698

Posted on 7 April 2014 | 8:29 pm


Triaryl-Substituted Schiff Bases Are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500268j

Posted on 7 April 2014 | 8:28 pm


Design, Synthesis, and Biological Evaluation of Novel Pyridine-Bridged Analogues of Combretastatin-A4 as Anticancer Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500002k

Posted on 7 April 2014 | 4:39 pm


Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401643m

Posted on 3 April 2014 | 8:48 pm


Discovery of a Highly Tumor-Selective Organometallic Ruthenium(II)–Arene Complex

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5002748

Posted on 2 April 2014 | 10:35 pm


Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500118j

Posted on 2 April 2014 | 9:56 pm


Synthesis, Structure–Activity Relationships, and Biological Studies of Chromenochalcones as Potential Antileishmanial Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401893j

Posted on 2 April 2014 | 9:55 pm


Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401992e

Posted on 2 April 2014 | 9:55 pm


New Pyrazolobenzothiazine Derivatives as Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401688h

Posted on 2 April 2014 | 9:54 pm


Strategies To Inhibit Tumor Associated Integrin Receptors: Rationale for Dual and Multi-Antagonists

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5000547

Posted on 7 March 2014 | 11:18 am


Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4011675

Posted on 6 March 2014 | 8:18 pm


The Current State of Drug Discovery and a Potential Role for NMR Metabolomics

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401803b

Posted on 3 March 2014 | 9:29 pm


Modulators of the Nuclear Receptor Retinoic Acid Receptor-Related Orphan Receptor-? (ROR? or RORc)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401901d

Posted on 24 February 2014 | 1:06 pm


Rings in Drugs

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4017625

Posted on 17 February 2014 | 12:04 pm


Switching Invariant Natural Killer T (iNKT) Cell Response from Anticancerous to Anti-Inflammatory Effect: Molecular Bases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4010863

Posted on 12 February 2014 | 4:35 pm


Foundation-Directed Therapeutic Development in Huntington’s Disease

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4009295

Posted on 4 February 2014 | 12:55 pm


Aldosterone Synthase Inhibitors as Promising Treatments for Mineralocorticoid Dependent Cardiovascular and Renal Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401430e

Posted on 24 January 2014 | 11:29 am


Discovery and Development of Janus Kinase (JAK) Inhibitors for Inflammatory Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401490p

Posted on 23 January 2014 | 7:08 pm


QSAR Modeling: Where Have You Been? Where Are You Going To?

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4004285

Posted on 6 January 2014 | 1:40 pm


Opportunities and Challenges in Developing Stearoyl-Coenzyme A Desaturase-1 Inhibitors as Novel Therapeutics for Human Disease

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401516c

Posted on 20 December 2013 | 11:53 am


Targeting Receptor Tyrosine Kinase MET in Cancer: Small Molecule Inhibitors and Clinical Progress

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401427c

Posted on 18 December 2013 | 11:36 am


Medicinal Chemistry of Inhibitors of 11?-Hydroxysteroid Dehydrogenase Type 1 (11?-HSD1)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4014746

Posted on 13 December 2013 | 8:37 pm


5-HT1A Receptor: An Old Target as a New Attractive Tool in Drug Discovery from Central Nervous System to Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400533t

Posted on 10 December 2013 | 8:02 pm


Prostanoid Receptor EP2 as a Therapeutic Target

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401431x

Posted on 4 December 2013 | 9:02 pm


Using Deuterium in Drug Discovery: Leaving the Label in the Drug

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4007998

Posted on 2 December 2013 | 8:25 pm


Recent Advances in the Discovery of Small Molecules Targeting Exchange Proteins Directly Activated by cAMP (EPAC)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401425e

Posted on 27 November 2013 | 1:12 pm


Toll-like Receptor 4 (TLR4) Modulation by Synthetic and Natural Compounds: An Update

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401006s

Posted on 20 November 2013 | 7:58 pm


Adenosine A2A Receptor as a Drug Discovery Target

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4011669

Posted on 15 November 2013 | 4:56 pm


MT1 and MT2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401343c

Posted on 14 November 2013 | 5:56 am


Molecular Similarity in Medicinal Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401411z

Posted on 11 November 2013 | 6:19 pm





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Chronological list of recent articles on Chemistry, Medicinal Chemistry, Journal of Medicinal Chemistry.
Update:
28.09.2013


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