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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



A Selective, Cell-Permeable Nonphosphorylated Bicyclic Peptidyl Inhibitor against Peptidyl–Prolyl Isomerase Pin1

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00411

Posted on 28 July 2015 | 9:54 pm


Synthesis of Thrombolytic Sol–Gel Coatings: Toward Drug-Entrapped Vascular Grafts

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00654

Posted on 28 July 2015 | 9:53 pm


Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00788

Posted on 28 July 2015 | 4:03 pm


Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00689

Posted on 28 July 2015 | 2:09 pm


Correction to Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00962

Posted on 27 July 2015 | 9:33 pm


Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00652

Posted on 24 July 2015 | 4:40 pm


Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00577

Posted on 24 July 2015 | 4:39 pm


High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00776

Posted on 23 July 2015 | 10:04 pm


Development of Quinoline-2,4(1H,3H)-diones as Potent and Selective Ligands of the Cannabinoid Type 2 Receptor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00227

Posted on 23 July 2015 | 4:26 pm


Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERB? and Autophagy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00511

Posted on 23 July 2015 | 3:59 pm


Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00226

Posted on 23 July 2015 | 3:59 pm


Structural Requirements for CNS Active Opioid Glycopeptides

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00014

Posted on 23 July 2015 | 3:58 pm


Applications of Fluorine in Medicinal Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00258

Posted on 22 July 2015 | 8:34 pm


Structure–Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00750

Posted on 22 July 2015 | 5:17 pm


Nucleoside Diphosphate Prodrugs: Nonsymmetric DiPPro-Nucleotides

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00737

Posted on 22 July 2015 | 2:00 pm


Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00741

Posted on 22 July 2015 | 6:58 am


Development of Safe and Effective Botanical Dietary Supplements

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00417

Posted on 21 July 2015 | 4:02 pm


Biological Efficacy and Toxicity of Diamidines in Myotonic Dystrophy Type 1 Models

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00356

Posted on 21 July 2015 | 3:59 pm


Structure–Affinity Relationships (SARs) and Structure–Kinetics Relationships (SKRs) of Kv11.1 Blockers

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00518

Posted on 17 July 2015 | 4:37 pm


Discovery and Optimization of a Porcupine Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00507

Posted on 16 July 2015 | 2:49 pm


N-Phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00775

Posted on 15 July 2015 | 7:33 pm


Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00171

Posted on 15 July 2015 | 5:51 pm


Fragment-Based Design of Selective Nanomolar Ligands of the CREBBP Bromodomain

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00172

Posted on 15 July 2015 | 5:51 pm


DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00150

Posted on 10 July 2015 | 10:14 pm


Regulation of the Apelinergic System and Its Potential in Cardiovascular Disease: Peptides and Small Molecules as Tools for Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00527

Posted on 10 July 2015 | 4:11 pm


Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00405

Posted on 6 July 2015 | 6:02 am


The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00313

Posted on 2 July 2015 | 10:34 pm


Therapeutic Potential of 5-HT6 Receptor Agonists

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00179

Posted on 2 July 2015 | 6:49 am


Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00229

Posted on 1 July 2015 | 8:05 pm


Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women’s Health

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00386

Posted on 12 June 2015 | 3:52 pm


Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00516

Posted on 3 June 2015 | 3:59 pm


Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00326

Posted on 26 May 2015 | 8:39 pm


Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00458

Posted on 20 May 2015 | 8:45 pm


Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501981g

Posted on 14 May 2015 | 8:28 pm


Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00261

Posted on 14 May 2015 | 7:10 pm


New Frontiers in Selective Human MAO-B Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501690r

Posted on 11 May 2015 | 6:53 am


Ligand Binding Thermodynamics in Drug Discovery: Still a Hot Tip?

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501511f

Posted on 11 May 2015 | 6:43 am


Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00256

Posted on 30 April 2015 | 2:00 pm


Activation of the ?-Aminobutyric Acid Type B (GABAB) Receptor by Agonists and Positive Allosteric Modulators

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5018913

Posted on 24 April 2015 | 8:07 pm


Progress Toward the Development of Noscapine and Derivatives as Anticancer Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501180v

Posted on 16 April 2015 | 1:59 pm


Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00209

Posted on 6 April 2015 | 2:30 pm


Volume of Distribution in Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00201

Posted on 1 April 2015 | 9:12 pm





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Chronological list of recent articles on Chemistry, Medicinal Chemistry, Journal of Medicinal Chemistry.
Update:
28.09.2013


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