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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



Synthesis and Structure–Activity Relationships of Pteridine Dione and Trione Monocarboxylate Transporter 1 Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500640x

Posted on 22 August 2014 | 8:06 pm


Human Toll-Like Receptor 8-Selective Agonistic Activities in 1-Alkyl-1H-benzimidazol-2-amines

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500701q

Posted on 20 August 2014 | 3:47 pm


Total Syntheses of Parthenolide and Its Analogues with Macrocyclic Stereocontrol

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5009456

Posted on 20 August 2014 | 1:10 pm


Water-Soluble and Cleavable Quercetin–Amino Acid Conjugates as Safe Modulators for P-Glycoprotein-Based Multidrug Resistance

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500290c

Posted on 20 August 2014 | 6:41 am


14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500262m

Posted on 19 August 2014 | 10:08 pm


Exploring the Influence of the Protein Environment on Metal-Binding Pharmacophores

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500984b

Posted on 19 August 2014 | 10:05 pm


Pyrano-isochromanones as IL-6 Inhibitors: Synthesis, in Vitro and in Vivo Antiarthritic Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500901e

Posted on 19 August 2014 | 10:04 pm


4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500448u

Posted on 19 August 2014 | 1:07 pm


Discovery of Mer Specific Tyrosine Kinase Inhibitors for the Treatment and Prevention of Thrombosis

Journal of Medicinal Chemistry
DOI: 10.1021/jm501217p

Posted on 18 August 2014 | 2:25 pm


Synthesis and Biological Evaluation of Novel Tacrine Derivatives and Tacrine–Coumarin Hybrids as Cholinesterase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5008648

Posted on 12 August 2014 | 8:37 pm


Design and Synthesis of Sulfamoyl Benzoic Acid Analogues with Subnanomolar Agonist Activity Specific to the LPA2 Receptor

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5007116

Posted on 12 August 2014 | 7:24 pm


Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500694p

Posted on 11 August 2014 | 7:50 pm


UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500749d

Posted on 6 August 2014 | 10:11 pm


A Potent Cyclic Peptide Targeting SPSB2 Protein as a Potential Anti-infective Agent

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500596j

Posted on 6 August 2014 | 10:10 pm


Rational Use of Plasma Protein and Tissue Binding Data in Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5007935

Posted on 6 August 2014 | 7:51 pm


Small Molecule Ghrelin Receptor Inverse Agonists and Antagonists

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5003183

Posted on 6 August 2014 | 2:20 pm


Current Compound Coverage of the Kinome

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5008159

Posted on 30 July 2014 | 8:49 pm


Optimization of Potent DFG-in Inhibitors of Platelet Derived Growth Factor Receptor? (PDGF-R?) Guided by Water Thermodynamics

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500373x

Posted on 21 July 2014 | 9:06 pm


Development of First Lead Structures for Phosphoinositide 3-Kinase-C2? Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5006034

Posted on 14 July 2014 | 3:00 pm


Toward Fluorescent Probes for G-Protein-Coupled Receptors (GPCRs)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401823z

Posted on 10 July 2014 | 9:01 pm


Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500766w

Posted on 10 July 2014 | 8:07 pm


Targeting the Androgen Receptor with Steroid Conjugates

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500101h

Posted on 8 July 2014 | 6:35 am


Discovery of Selective and Orally Bioavailable Protein Kinase C? (PKC?) Inhibitors from a Fragment Hit

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500669m

Posted on 7 July 2014 | 10:10 pm


Recent Developments in Novel Antidepressants Targeting ?4?2-Nicotinic Acetylcholine Receptors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401937a

Posted on 2 July 2014 | 10:11 pm


Polypharmacology: Challenges and Opportunities in Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5006463

Posted on 25 June 2014 | 10:27 pm


Calcitonin Gene-Related Peptide Receptor Antagonists: New Therapeutic Agents for Migraine

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500364u

Posted on 24 June 2014 | 10:26 pm


Development of Synthetic Lethality Anticancer Therapeutics

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500415t

Posted on 13 June 2014 | 8:52 pm


Elements and Modulation of Functional Dynamics

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500325k

Posted on 10 June 2014 | 2:08 pm


Physicochemical Descriptors of Aromatic Character and Their Use in Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500515d

Posted on 3 June 2014 | 10:51 pm


Serotonin 5-HT6 Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer’s Disease

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5003952

Posted on 3 June 2014 | 7:05 pm


The Medicinal Chemistry of Liver X Receptor (LXR) Modulators

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500442z

Posted on 28 May 2014 | 9:12 pm


Small Molecule Inhibitors Targeting Activator Protein 1 (AP-1)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5004733

Posted on 27 May 2014 | 1:27 pm


Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase ?

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500362j

Posted on 2 May 2014 | 12:44 pm


Biased Ligand Modulation of Seven Transmembrane Receptors (7TMRs): Functional Implications for Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401677g

Posted on 29 April 2014 | 4:06 pm


Successes and Challenges in Phenotype-Based Lead Discovery for Prion Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5001425

Posted on 24 April 2014 | 3:36 pm


Nucleotide-Binding Oligomerization Domain (NOD) Inhibitors: A Rational Approach toward Inhibition of NOD Signaling Pathway

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401841p

Posted on 22 April 2014 | 8:02 pm





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Chronological list of recent articles on Chemistry, Medicinal Chemistry, Journal of Medicinal Chemistry.
Update:
28.09.2013


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