Journal of Medicinal Chemistry

Current research reports and chronological list of recent articles.


The international scientific Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

The publisher is the American Chemical Society, ACS. The copyright and publishing rights of specialized products listed below are in this publishing house. This is also responsible for the content shown.

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Additional research articles see Current Chemistry Research Articles. Magazines with similar content (medicinal chemistry):

 - Bioorganic and Medicinal Chemistry Letters,

 - European Journal of Medicinal Chemistry.

 - Journal of Enzyme Inhibition and Medicinal Chemistry,

 - Medicinal Chemistry Research,



Journal of Medicinal Chemistry - Abstracts



Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00719

Datum: 24.06.2016


Gramine Derivatives Targeting Ca2+ Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00478

Datum: 24.06.2016


Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00044

Datum: 22.06.2016


Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00610

Datum: 22.06.2016


Fragment-Based Identification of Influenza Endonuclease Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00628

Datum: 22.06.2016


Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00415

Datum: 22.06.2016


Design, Synthesis, and In Vitro and In Vivo Evaluation of an 18F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00390

Datum: 22.06.2016


Discovery and Rational Design of Pteridin-7(8H)-one-Based Inhibitors Targeting FMS-like Tyrosine Kinase 3 (FLT3) and Its Mutants

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00374

Datum: 22.06.2016


High Affinity Agonists of the Neuropeptide Y (NPY) Y4 Receptor Derived from the C-Terminal Pentapeptide of Human Pancreatic Polypeptide (hPP): Synthesis, Stereochemical Discrimination, and Radiolabeling

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00309

Datum: 22.06.2016


Jatrophane Diterpenoids as Modulators of P-Glycoprotein-Dependent Multidrug Resistance (MDR): Advances of Structure–Activity Relationships and Discovery of Promising MDR Reversal Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00605

Datum: 21.06.2016


Could Killing Bacterial Subpopulations Hit Tuberculosis out of the Park?

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00875

Datum: 20.06.2016


Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of the Breast Cancer Resistance Protein (ABCG2)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00035

Datum: 17.06.2016


3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00040

Datum: 17.06.2016


Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00028

Datum: 17.06.2016


Optimization of Cyclic Plasmin Inhibitors: From Benzamidines to Benzylamines

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00606

Datum: 17.06.2016


Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01833

Datum: 17.06.2016


Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00519

Datum: 16.06.2016


Endothelin-Receptor Antagonists beyond Pulmonary Arterial Hypertension: Cancer and Fibrosis

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01781

Datum: 15.06.2016


Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00150

Datum: 03.06.2016


β-Lactamases: Why and How

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00448

Datum: 27.05.2016


Carbon Nanotubes in Biomedical Applications: Factors, Mechanisms, and Remedies of Toxicity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01770

Datum: 27.05.2016


Design Principles for Fragment Libraries: Maximizing the Value of Learnings from Pharma Fragment-Based Drug Discovery (FBDD) Programs for Use in Academia

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00197

Datum: 16.05.2016


Challenges and Opportunities for the Application of Boron Clusters in Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01932

Datum: 10.05.2016


From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer’s Disease?

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00151

Datum: 06.05.2016


Polymerase Acidic Protein–Basic Protein 1 (PA–PB1) Protein–Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01474

Datum: 19.04.2016


Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01516

Datum: 18.04.2016


Artemisinin-Derived Dimers: Potent Antimalarial and Anticancer Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01380

Datum: 06.04.2016


Gamma Secretase Modulators: New Alzheimer’s Drugs on the Horizon?

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01960

Datum: 05.04.2016


Ten Years of Medicinal Chemistry (2005–2014) in the Journal of Medicinal Chemistry: Country of Contributors, Topics, and Public–Private Partnerships

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01349

Datum: 05.04.2016


Integrating Everything: The Molecule Selection Toolkit, a System for Compound Prioritization in Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01338

Datum: 22.03.2016


PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01813

Datum: 18.03.2016


Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01499

Datum: 14.03.2016


Targeting the Bacterial Division Protein FtsZ

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01098

Datum: 10.03.2016


An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01461

Datum: 29.02.2016


Recent Progress on Bile Acid Receptor Modulators for Treatment of Metabolic Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00342

Datum: 29.02.2016


Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00840

Datum: 26.02.2016


Chemical Space of DNA-Encoded Libraries

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01874

Datum: 25.02.2016


Design and Development of Microsomal Prostaglandin E2 Synthase-1 Inhibitors: Challenges and Future Directions

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01750

Datum: 24.02.2016


Lanthanides: Applications in Cancer Diagnosis and Therapy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01975

Datum: 19.02.2016


Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01698

Datum: 18.02.2016


Quadruplex Nucleic Acids as Novel Therapeutic Targets

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01835

Datum: 16.02.2016






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