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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



Correction to “Design, Synthesis, and Structure–Activity Relationship of a Novel Series of GluN2C-Selective Potentiators”

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00199

Posted on 4 March 2015 | 7:52 pm


Tailored Near-Infrared Contrast Agents for Image Guided Surgery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00253

Posted on 4 March 2015 | 7:39 pm


Identification of Novel Aldose Reductase Inhibitors Based on Carboxymethylated Mercaptotriazinoindole Scaffold

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5015814

Posted on 4 March 2015 | 6:17 am


Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501913a

Posted on 3 March 2015 | 8:31 pm


Phthalocyanine Derivatives Possessing 2-(Morpholin-4-yl)ethoxy Groups As Potential Agents for Photodynamic Therapy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00052

Posted on 3 March 2015 | 5:10 pm


A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501853m

Posted on 3 March 2015 | 2:48 pm


Stem Cell Mobilizers Targeting Chemokine Receptor CXCR4: Renoprotective Application in Acute Kidney Injury

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501769r

Posted on 2 March 2015 | 5:25 pm


Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501790e

Posted on 27 February 2015 | 10:33 pm


Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501963e

Posted on 26 February 2015 | 8:57 pm


Development of a Novel Class of Tubulin Inhibitor from Desmosdumotin B with a Hydroxylated Bicyclic B-Ring

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501859j

Posted on 26 February 2015 | 7:59 pm


A Binding Mode Hypothesis of Tiagabine Confirms Liothyronine Effect on ?-Aminobutyric Acid Transporter 1 (GAT1)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5015428

Posted on 26 February 2015 | 5:31 pm


Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501258m

Posted on 26 February 2015 | 1:37 pm


Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501660t

Posted on 26 February 2015 | 6:23 am


Structure-Based Lead Optimization and Biological Evaluation of BAX Direct Activators as Novel Potential Anticancer Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501123r

Posted on 25 February 2015 | 10:27 pm


Design and Optimization of a Series of 1-Sulfonylpyrazolo[4,3-b]pyridines as Selective c-Met Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm502018y

Posted on 25 February 2015 | 8:01 pm


Strong Antibacterial Properties of Anion Transporters: A Result of Depolarization and Weakening of the Bacterial Membrane

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501979f

Posted on 25 February 2015 | 8:00 pm


Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5017544

Posted on 25 February 2015 | 7:51 pm


Learning from PAINful lessons

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00294

Posted on 24 February 2015 | 5:51 pm


C-Terminal Modifications of Apelin-13 Significantly Change Ligand Binding, Receptor Signaling, and Hypotensive Action

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501916k

Posted on 24 February 2015 | 5:36 pm


Discovery of Novel 2,5-Dioxoimidazolidine-Based P2X7 Receptor Antagonists as Constrained Analogues of KN62

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500324g

Posted on 23 February 2015 | 3:07 pm


Selective, Nontoxic CB2 Cannabinoid o-Quinone with in Vivo Activity against Triple-Negative Breast Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00078

Posted on 20 February 2015 | 9:20 pm


Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501518y

Posted on 20 February 2015 | 9:20 pm


Synthetic Nucleic Acid Delivery Systems: Present and Perspectives

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500330k

Posted on 20 February 2015 | 8:04 pm


FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501524q

Posted on 20 February 2015 | 2:48 pm


Understanding Our Love Affair with p-Chlorophenyl: Present Day Implications from Historical Biases of Reagent Selection

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501894t

Posted on 19 February 2015 | 5:47 pm


Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501765v

Posted on 19 February 2015 | 5:37 pm


Synthesis and Biological Evaluation of Indolyl-Pyridinyl-Propenones Having Either Methuosis or Microtubule Disruption Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501997q

Posted on 19 February 2015 | 2:15 pm


Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501778s

Posted on 18 February 2015 | 10:45 pm


Design, Synthesis, and Biological Evaluation of Theranostic Vitamin–Linker–Taxoid Conjugates

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5019115

Posted on 18 February 2015 | 5:12 pm


Selective Nonpeptidic Fluorescent Ligands for Oxytocin Receptor: Design, Synthesis, and Application to Time-Resolved FRET Binding Assay

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501395b

Posted on 12 February 2015 | 9:13 pm


Bronchodilating Drugs for Chronic Obstructive Pulmonary Disease: Current Status and Future Trends

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5013227

Posted on 9 February 2015 | 5:58 pm


Progress in Discovery of KIF5B-RET Kinase Inhibitors for the Treatment of Non-Small-Cell Lung Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501464c

Posted on 4 February 2015 | 7:43 pm


(Dis)similar Analogues of Riboswitch Metabolites as Antibacterial Lead Compounds

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500868e

Posted on 3 February 2015 | 4:27 pm


Discovery and Development of Galeterone (TOK-001 or VN/124-1) for the Treatment of All Stages of Prostate Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501239f

Posted on 28 January 2015 | 9:40 pm


Small Molecule Discoidin Domain Receptor Kinase Inhibitors and Potential Medical Applications

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5012319

Posted on 21 January 2015 | 9:36 pm


Stemistry: The Control of Stem Cells in Situ Using Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500838d

Posted on 15 January 2015 | 8:04 pm


Organic Carbamates in Drug Design and Medicinal Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501371s

Posted on 7 January 2015 | 2:38 pm


CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501535r

Posted on 6 January 2015 | 8:55 pm


Targeting DNA Methylation with Small Molecules: What’s Next?

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500843d

Posted on 4 December 2014 | 8:50 pm


Parallel Worlds of Public and Commercial Bioactive Chemistry Data

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5011308

Posted on 4 December 2014 | 6:35 am


Targeting Aldose Reductase for the Treatment of Diabetes Complications and Inflammatory Diseases: New Insights and Future Directions

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500907a

Posted on 17 November 2014 | 8:47 pm





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28.09.2013


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