Journal of Medicinal Chemistry

Current research reports and chronological list of recent articles.


The international scientific Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

The publisher is the American Chemical Society, ACS. The copyright and publishing rights of specialized products listed below are in this publishing house. This is also responsible for the content shown.

To search this web page for specific words type "Ctrl" + "F" on your keyboard (Command + "F" on a Mac). Then: type the word you are searching for in the window that pops up!

Additional research articles see Current Chemistry Research Articles. Magazines with similar content (medicinal chemistry):

 - Bioorganic and Medicinal Chemistry Letters,

 - European Journal of Medicinal Chemistry.

 - Journal of Enzyme Inhibition and Medicinal Chemistry,

 - Medicinal Chemistry Research,



Journal of Medicinal Chemistry - Abstracts



Therapeutic Potential of Foldamers: From Chemical Biology Tools To Drug Candidates?

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00376

Datum: 29.07.2016


The Medicinal Chemistry of Therapeutic Oligonucleotides

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00551

Datum: 29.07.2016


Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00564

Datum: 28.07.2016


An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00055

Datum: 27.07.2016


Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00799

Datum: 27.07.2016


Discovery and Structure–Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00356

Datum: 26.07.2016


Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00777

Datum: 26.07.2016


l-Cystine Diamides as l-Cystine Crystallization Inhibitors for Cystinuria

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00647

Datum: 26.07.2016


Discovery of Novel Polo-Like Kinase 1 Polo-Box Domain Inhibitors to Induce Mitotic Arrest in Tumor Cells

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00261

Datum: 26.07.2016


Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00411

Datum: 25.07.2016


Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430)

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00827

Datum: 25.07.2016


Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b02038

Datum: 22.07.2016


Design, Synthesis, and Initial Evaluation of Affinity-Based Small-Molecule Probes for Fluorescent Visualization and Specific Detection of Keap1

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00775

Datum: 22.07.2016


Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00428

Datum: 22.07.2016


Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein–Ligand Residence Times

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00632

Datum: 22.07.2016


Synthesis of Fluorescent Binaphthyl Amines That Bind c-MYC G-Quadruplex DNA and Repress c-MYC Expression

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00328

Datum: 21.07.2016


Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00403

Datum: 21.07.2016


Design, Synthesis, and Identification of 4″α-Azidoethyl-cyclic ADP-Carbocyclic-ribose as a Highly Potent Analogue of Cyclic ADP-Ribose, a Ca2+-Mobilizing Second Messenger

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00437

Datum: 20.07.2016


Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00486

Datum: 20.07.2016


Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00746

Datum: 20.07.2016


Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00709

Datum: 20.07.2016


Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00596

Datum: 19.07.2016


Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844)

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00280

Datum: 13.07.2016


Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00680

Datum: 12.07.2016


Underexplored Opportunities for Natural Products in Drug Discovery

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00473

Datum: 11.07.2016


G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01939

Datum: 08.07.2016


Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00730

Datum: 07.07.2016


The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00472

Datum: 30.06.2016


Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00463

Datum: 27.06.2016


Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01335

Datum: 27.06.2016


Endothelin-Receptor Antagonists beyond Pulmonary Arterial Hypertension: Cancer and Fibrosis

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01781

Datum: 15.06.2016


Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00150

Datum: 03.06.2016


β-Lactamases: Why and How

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00448

Datum: 27.05.2016


Carbon Nanotubes in Biomedical Applications: Factors, Mechanisms, and Remedies of Toxicity

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01770

Datum: 27.05.2016


Design Principles for Fragment Libraries: Maximizing the Value of Learnings from Pharma Fragment-Based Drug Discovery (FBDD) Programs for Use in Academia

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00197

Datum: 16.05.2016


Challenges and Opportunities for the Application of Boron Clusters in Drug Design

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01932

Datum: 10.05.2016


From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer’s Disease?

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00151

Datum: 06.05.2016


Polymerase Acidic Protein–Basic Protein 1 (PA–PB1) Protein–Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01474

Datum: 19.04.2016


Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01516

Datum: 18.04.2016


Artemisinin-Derived Dimers: Potent Antimalarial and Anticancer Agents

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01380

Datum: 06.04.2016


Gamma Secretase Modulators: New Alzheimer’s Drugs on the Horizon?

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01960

Datum: 05.04.2016


Ten Years of Medicinal Chemistry (2005–2014) in the Journal of Medicinal Chemistry: Country of Contributors, Topics, and Public–Private Partnerships

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01349

Datum: 05.04.2016


Integrating Everything: The Molecule Selection Toolkit, a System for Compound Prioritization in Drug Discovery

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01338

Datum: 22.03.2016


PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01813

Datum: 18.03.2016


Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01499

Datum: 14.03.2016


Targeting the Bacterial Division Protein FtsZ

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01098

Datum: 10.03.2016






Information about this site:

Last update: 05.02.2016

The author- or copyrights of the listed Internet pages are held by the respective authors or site operators, who are also responsible for the content of the presentations.

To see your page listed here: Send us an eMail! Condition: Subject-related content on chemistry, biochemistry and comparable academic disciplines!

Topic: Current, research, scientific, medicinal, chemistry, recent, journal, list, articles.






(C) 1996 - 2016 Internetchemistry













Current Chemistry Job Vacancies:

[more job vacancies]