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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



Current Compound Coverage of the Kinome

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5008159

Posted on 30 July 2014 | 8:49 pm


A Novel Class of Bis- and Tris-Chelate Diam(m)inebis(dicarboxylato)platinum(IV) Complexes as Potential Anticancer Prodrugs

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500791c

Posted on 30 July 2014 | 2:52 pm


Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500483b

Posted on 29 July 2014 | 12:31 pm


Synthesis, Antimitotic and Antivascular Activity of 1-(3?,4?,5?-Trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5008193

Posted on 28 July 2014 | 10:20 pm


Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5006176

Posted on 28 July 2014 | 5:02 pm


Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500871s

Posted on 25 July 2014 | 10:12 pm


Anti-HIV Activities of Precisely Defined, Semirigid, Carboxylated Alternating Copolymers

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401913w

Posted on 25 July 2014 | 9:38 pm


Discovery of Potent Cytotoxic Ortho-Aryl Chalcones as New Scaffold Targeting Tubulin and Mitosis with Affinity-Based Fluorescence

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500024v

Posted on 25 July 2014 | 4:58 pm


Constrained Bithiazoles: Small Molecule Correctors of Defective ?F508–CFTR Protein Trafficking

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5007885

Posted on 25 July 2014 | 4:23 pm


Discovery of 1H-Indole-2-carboxamides as Novel Inhibitors of the Androgen Receptor Binding Function 3 (BF3)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500684r

Posted on 25 July 2014 | 12:36 pm


Studies Examining the Relationship between the Chemical Structure of Protoxin II and Its Activity on Voltage Gated Sodium Channels

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500687u

Posted on 24 July 2014 | 7:47 pm


Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5007275

Posted on 24 July 2014 | 3:53 pm


Discovery of Glycine Sulfonamides as Dual Inhibitors of sn-1-Diacylglycerol Lipase ? and ?/?-Hydrolase Domain 6

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500681z

Posted on 23 July 2014 | 7:20 pm


[111In-DOTA]LTT-SS28, a First Pansomatostatin Radioligand for in Vivo Targeting of Somatostatin Receptor-Positive Tumors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500581d

Posted on 23 July 2014 | 7:20 pm


N-Tetradecylcarbamyl Lipopeptides as Novel Agonists for Toll-like Receptor 2

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500722p

Posted on 23 July 2014 | 5:46 pm


Optimization of Potent DFG-in Inhibitors of Platelet Derived Growth Factor Receptor? (PDGF-R?) Guided by Water Thermodynamics

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500373x

Posted on 21 July 2014 | 9:06 pm


N-Aryl-2-aminobenzimidazoles: Novel, Efficacious, Antimalarial Lead Compounds

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500715u

Posted on 21 July 2014 | 7:04 pm


Modification and Biological Evaluation of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500724x

Posted on 18 July 2014 | 9:50 pm


Discovery of Selective Hexapeptide Agonists to Human Neuromedin U Receptors Types 1 and 2

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500599s

Posted on 18 July 2014 | 4:47 pm


Putative Kappa Opioid Heteromers As Targets for Developing Analgesics Free of Adverse Effects

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500159d

Posted on 18 July 2014 | 4:45 pm


Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500191u

Posted on 17 July 2014 | 8:21 pm


Method for the Evaluation of Structure–Activity Relationship Information Associated with Coordinated Activity Cliffs

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500577n

Posted on 17 July 2014 | 5:46 pm


Indazole- and Indole-5-carboxamides: Selective and Reversible Monoamine Oxidase B Inhibitors with Subnanomolar Potency

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500729a

Posted on 16 July 2014 | 9:41 pm


Development and Biological Evaluation of Potent and Selective c-KITD816V Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500413g

Posted on 16 July 2014 | 5:51 pm


Diarylthiazole: An Antimycobacterial Scaffold Potentially Targeting PrrB-PrrA Two-Component System

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500833f

Posted on 16 July 2014 | 2:30 pm


Development of First Lead Structures for Phosphoinositide 3-Kinase-C2? Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5006034

Posted on 14 July 2014 | 3:00 pm


Toward Fluorescent Probes for G-Protein-Coupled Receptors (GPCRs)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401823z

Posted on 10 July 2014 | 9:01 pm


Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500766w

Posted on 10 July 2014 | 8:07 pm


Discovery of a Small Molecule MDM2 Inhibitor (AMG 232) for Treating Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500627s

Posted on 9 July 2014 | 9:45 pm


Targeting the Androgen Receptor with Steroid Conjugates

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500101h

Posted on 8 July 2014 | 6:35 am


Discovery of Selective and Orally Bioavailable Protein Kinase C? (PKC?) Inhibitors from a Fragment Hit

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500669m

Posted on 7 July 2014 | 10:10 pm


Recent Developments in Novel Antidepressants Targeting ?4?2-Nicotinic Acetylcholine Receptors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401937a

Posted on 2 July 2014 | 10:11 pm


Polypharmacology: Challenges and Opportunities in Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5006463

Posted on 25 June 2014 | 10:27 pm


Calcitonin Gene-Related Peptide Receptor Antagonists: New Therapeutic Agents for Migraine

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500364u

Posted on 24 June 2014 | 10:26 pm


Development of Synthetic Lethality Anticancer Therapeutics

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500415t

Posted on 13 June 2014 | 8:52 pm


Elements and Modulation of Functional Dynamics

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500325k

Posted on 10 June 2014 | 2:08 pm


Physicochemical Descriptors of Aromatic Character and Their Use in Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500515d

Posted on 3 June 2014 | 10:51 pm


Serotonin 5-HT6 Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer’s Disease

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5003952

Posted on 3 June 2014 | 7:05 pm


The Medicinal Chemistry of Liver X Receptor (LXR) Modulators

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500442z

Posted on 28 May 2014 | 9:12 pm


Small Molecule Inhibitors Targeting Activator Protein 1 (AP-1)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5004733

Posted on 27 May 2014 | 1:27 pm


Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase ?

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500362j

Posted on 2 May 2014 | 12:44 pm


Biased Ligand Modulation of Seven Transmembrane Receptors (7TMRs): Functional Implications for Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401677g

Posted on 29 April 2014 | 4:06 pm


Successes and Challenges in Phenotype-Based Lead Discovery for Prion Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5001425

Posted on 24 April 2014 | 3:36 pm


Nucleotide-Binding Oligomerization Domain (NOD) Inhibitors: A Rational Approach toward Inhibition of NOD Signaling Pathway

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401841p

Posted on 22 April 2014 | 8:02 pm


Motor Neuron Disease: A Chemical Perspective

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5001584

Posted on 17 April 2014 | 3:27 pm


Strategies To Inhibit Tumor Associated Integrin Receptors: Rationale for Dual and Multi-Antagonists

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5000547

Posted on 7 March 2014 | 11:18 am


Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4011675

Posted on 6 March 2014 | 8:18 pm





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Chronological list of recent articles on Chemistry, Medicinal Chemistry, Journal of Medicinal Chemistry.
Update:
28.09.2013


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