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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



Structure–Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00407

Posted on 21 May 2015 | 7:50 pm


Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00458

Posted on 20 May 2015 | 8:45 pm


Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00473

Posted on 20 May 2015 | 5:27 pm


Design, Synthesis, and Biological Evaluation of Hexacyclic Tetracyclines as Potent, Broad Spectrum Antibacterial Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00262

Posted on 20 May 2015 | 1:44 pm


Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00128

Posted on 20 May 2015 | 1:42 pm


Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00330

Posted on 20 May 2015 | 1:42 pm


Cyclopentadienyl–Ruthenium(II) and Iron(II) Organometallic Compounds with Carbohydrate Derivative Ligands as Good Colorectal Anticancer Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00403

Posted on 15 May 2015 | 4:12 pm


Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501981g

Posted on 14 May 2015 | 8:28 pm


Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00261

Posted on 14 May 2015 | 7:10 pm


Synthesis and Evaluation of 1,2,4-Triazolo[1,5-a]pyrimidines as Antibacterial Agents Against Enterococcus faecium

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501831g

Posted on 12 May 2015 | 5:31 pm


New Frontiers in Selective Human MAO-B Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501690r

Posted on 11 May 2015 | 6:53 am


Ligand Binding Thermodynamics in Drug Discovery: Still a Hot Tip?

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501511f

Posted on 11 May 2015 | 6:43 am


Correlating Molecular Character of NIR Imaging Agents with Tissue-Specific Uptake

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00475

Posted on 8 May 2015 | 10:10 pm


Design of Highly Potent Urea-Based, Exosite-Binding Inhibitors Selective for Glutamate Carboxypeptidase II

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00278

Posted on 7 May 2015 | 10:15 pm


Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the ?-Opioid Receptor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00007

Posted on 7 May 2015 | 3:10 pm


Rational Design of Dual Peptides Targeting Ghrelin and Y2 Receptors to Regulate Food Intake and Body Weight

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501702q

Posted on 7 May 2015 | 1:37 pm


Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00144

Posted on 7 May 2015 | 1:12 pm


Selenium-Containing Chrysin and Quercetin Derivatives: Attractive Scaffolds for Cancer Therapy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00230

Posted on 7 May 2015 | 1:12 pm


Design, Synthesis, and Biological Evaluation of Novel, Highly Active Soft ROCK Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00308

Posted on 6 May 2015 | 7:10 pm


Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00256

Posted on 30 April 2015 | 2:00 pm


Activation of the ?-Aminobutyric Acid Type B (GABAB) Receptor by Agonists and Positive Allosteric Modulators

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5018913

Posted on 24 April 2015 | 8:07 pm


Progress Toward the Development of Noscapine and Derivatives as Anticancer Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501180v

Posted on 16 April 2015 | 1:59 pm


Peroxisome Proliferator-Activated Receptor ? (PPAR?) and Ligand Choreography: Newcomers Take the Stage

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501155f

Posted on 9 April 2015 | 4:30 pm


Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00209

Posted on 6 April 2015 | 2:30 pm


Volume of Distribution in Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00201

Posted on 1 April 2015 | 9:12 pm


Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501512b

Posted on 31 March 2015 | 3:31 pm


Clostridium difficile Drug Pipeline: Challenges in Discovery and Development of New Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5016846

Posted on 30 March 2015 | 8:15 pm


Fighting Malaria: Structure-Guided Discovery of Nonpeptidomimetic Plasmepsin Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5014133

Posted on 17 March 2015 | 2:02 pm


Origins of the Quinolone Class of Antibacterials: An Expanded “Discovery Story”

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501881c

Posted on 12 March 2015 | 8:02 pm


The Hippo Pathway and YAP/TAZ–TEAD Protein–Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501615v

Posted on 11 March 2015 | 7:46 pm


A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501853m

Posted on 3 March 2015 | 1:48 pm


Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5017544

Posted on 25 February 2015 | 6:51 pm


Synthetic Nucleic Acid Delivery Systems: Present and Perspectives

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500330k

Posted on 20 February 2015 | 7:04 pm


Bronchodilating Drugs for Chronic Obstructive Pulmonary Disease: Current Status and Future Trends

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5013227

Posted on 9 February 2015 | 4:58 pm





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Chronological list of recent articles on Chemistry, Medicinal Chemistry, Journal of Medicinal Chemistry.
Update:
28.09.2013


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