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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5013984

Posted on 23 October 2014 | 9:52 pm


Targeting Nucleus DNA with a Cyclometalated Dipyridophenazineruthenium(II) Complex

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501095r

Posted on 23 October 2014 | 9:50 pm


Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500847m

Posted on 22 October 2014 | 8:02 pm


Orally Bioavailable 6-Chloro-7-methoxy-4(1H)-quinolones Efficacious against Multiple Stages of Plasmodium

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500942v

Posted on 22 October 2014 | 3:24 pm


Oligonucleotide Analogues as Modulators of the Expression and Function of Noncoding RNAs (ncRNAs): Emerging Therapeutics Applications

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5006594

Posted on 21 October 2014 | 7:26 pm


Trehalose- and Glucose-Derived Glycoamphiphiles: Small-Molecule and Nanoparticle Toll-Like Receptor 4 (TLR4) Modulators

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501182w

Posted on 21 October 2014 | 5:45 pm


Nonpeptide Small Molecule Agonist and Antagonist Original Leads for Neuropeptide FF1 and FF2 Receptors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500989n

Posted on 21 October 2014 | 1:04 pm


Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500850y

Posted on 20 October 2014 | 6:29 am


Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501174m

Posted on 17 October 2014 | 6:03 am


Design, Synthesis, and Antibacterial Properties of Dual-Ligand Inhibitors of Acetyl-CoA Carboxylase

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501082n

Posted on 15 October 2014 | 7:48 pm


Targeting Matrix Metalloproteinases: Exploring the Dynamics of the S1? Pocket in the Design of Selective, Small Molecule Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500505f

Posted on 10 October 2014 | 6:30 am


Optimized Protein Kinase C? (PKC?) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5013006

Posted on 9 October 2014 | 9:29 pm


Discovery and Characterization of MAPK-activated Protein Kinase-2 Prevention of Activation Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501038s

Posted on 9 October 2014 | 9:27 pm


Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500734a

Posted on 8 October 2014 | 5:04 pm


Beyond C, H, O, and N! Analysis of the Elemental Composition of U.S. FDA Approved Drug Architectures

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501105n

Posted on 6 October 2014 | 7:27 pm


Development of Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5010978

Posted on 25 September 2014 | 2:48 pm


Peptides Containing ?-Amino Acid Patterns: Challenges and Successes in Medicinal Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5010896

Posted on 24 September 2014 | 3:38 pm


Acidic and Basic Drugs in Medicinal Chemistry: A Perspective

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501000a

Posted on 18 September 2014 | 4:30 pm


Exploring the Scaffold Universe of Kinase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501237k

Posted on 16 September 2014 | 4:24 pm


Positron Emission Tomography in CNS Drug Discovery and Drug Monitoring

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5001858

Posted on 10 September 2014 | 9:42 pm


Natural Products in Medicine: Transformational Outcome of Synthetic Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500941m

Posted on 10 September 2014 | 8:46 pm


Desferrithiocin: A Search for Clinically Effective Iron Chelators

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500828f

Posted on 10 September 2014 | 8:46 pm


Medicinal Chemistry of Catechol O-Methyltransferase (COMT) Inhibitors and Their Therapeutic Utility

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500572b

Posted on 2 September 2014 | 11:08 pm


Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500823a

Posted on 29 August 2014 | 6:37 am


Small Molecule Adenosine 5?-Monophosphate Activated Protein Kinase (AMPK) Modulators and Human Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401994c

Posted on 28 August 2014 | 9:44 pm


Small Molecule Ghrelin Receptor Inverse Agonists and Antagonists

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5003183

Posted on 6 August 2014 | 2:20 pm


Current Compound Coverage of the Kinome

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5008159

Posted on 30 July 2014 | 8:49 pm


Optimization of Potent DFG-in Inhibitors of Platelet Derived Growth Factor Receptor? (PDGF-R?) Guided by Water Thermodynamics

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500373x

Posted on 21 July 2014 | 9:06 pm


Development of First Lead Structures for Phosphoinositide 3-Kinase-C2? Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5006034

Posted on 14 July 2014 | 3:00 pm


Discovery of Selective and Orally Bioavailable Protein Kinase C? (PKC?) Inhibitors from a Fragment Hit

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500669m

Posted on 7 July 2014 | 10:10 pm


Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase ?

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500362j

Posted on 2 May 2014 | 12:44 pm





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Chronological list of recent articles on Chemistry, Medicinal Chemistry, Journal of Medicinal Chemistry.
Update:
28.09.2013


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