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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4000837

Posted on 17 May 2013 | 1:59 pm


Matrix Metalloproteinase Inhibitors Based on the 3-Mercaptopyrrolidine Core

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400529f

Posted on 16 May 2013 | 7:49 pm


Xanthates and Trithiocarbonates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Effects in Vivo

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400414j

Posted on 16 May 2013 | 3:55 pm


Discovery of Novel STAT3 Small Molecule Inhibitors via in Silico Site-Directed Fragment-Based Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400080c

Posted on 16 May 2013 | 2:47 pm


Enantioselective Inhibition of Microbial Lipolytic Enzymes by Nonracemic Monocyclic Enolphosphonate Analogues of Cyclophostin

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4000787

Posted on 16 May 2013 | 2:45 pm


Development and Therapeutic Implications of Selective Histone Deacetylase 6 Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4001659

Posted on 15 May 2013 | 2:59 pm


Design, Synthesis, and Inhibitory Activity of Potent, Photoswitchable Mast Cell Activation Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400115k

Posted on 15 May 2013 | 2:58 pm


Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain

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Journal of Medicinal Chemistry
DOI: 10.1021/jm301793a

Posted on 14 May 2013 | 8:15 pm


Novel Adamantyl Cannabinoids as CB1 Receptor Probes

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Journal of Medicinal Chemistry
DOI: 10.1021/jm4000775

Posted on 14 May 2013 | 5:47 pm


Small-Molecule Inhibitors of Cytokine-Mediated STAT1 Signal Transduction in ?-Cells with Improved Aqueous Solubility

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400397x

Posted on 13 May 2013 | 8:24 pm


Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5?-Monophosphate Dehydrogenase

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400241j

Posted on 13 May 2013 | 3:05 pm


Oxadiazole-isopropylamides as Potent and Noncovalent Proteasome Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400221d

Posted on 13 May 2013 | 6:56 am


Synthesis and in Vitro and in Vivo Characterization of Highly ?1-Selective ?-Adrenoceptor Partial Agonists

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400348g

Posted on 10 May 2013 | 10:26 pm


Efficacious Cyclic N-Acyl O-Amino Phenol Duocarmycin Prodrugs

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400413r

Posted on 10 May 2013 | 10:24 pm


Site-Specific and Far-Red-Light-Activatable Prodrug of Combretastatin A-4 Using Photo-Unclick Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400139w

Posted on 10 May 2013 | 8:26 pm


Structure-Based Approaches to Ligands for G-Protein-Coupled Adenosine and P2Y Receptors, from Small Molecules to Nanoconjugates

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400422s

Posted on 9 May 2013 | 10:10 pm


Sustainable Practices in Medicinal Chemistry: Current State and Future Directions

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400250p

Posted on 9 May 2013 | 10:08 pm


Diastereotopic and Deuterium Effects in Gemini

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400032t

Posted on 9 May 2013 | 3:01 pm


A New Face for Old Antibiotics: Tetracyclines in Treatment of Amyloidoses

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400161p

Posted on 8 May 2013 | 2:02 pm


A Potent Bivalent Smac Mimetic (SM-1200) Achieving Rapid, Complete, and Durable Tumor Regression in Mice

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400216d

Posted on 7 May 2013 | 10:13 pm


Inhibition of Rhodesain as a Novel Therapeutic Modality for Human African Trypanosomiasis

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Journal of Medicinal Chemistry
DOI: 10.1021/jm301424d

Posted on 7 May 2013 | 9:03 pm


Discovery of a New Class of Natural Product-Inspired Quinazolinone Hybrid as Potent Antileishmanial agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400053v

Posted on 7 May 2013 | 7:06 pm


Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400293z

Posted on 6 May 2013 | 10:07 pm


Increasing the Efficiency of Ligands for FK506-Binding Protein 51 by Conformational Control

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400087k

Posted on 6 May 2013 | 4:30 pm


Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm301234k

Posted on 6 May 2013 | 4:29 pm


?-Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400225m

Posted on 2 May 2013 | 7:37 pm


Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400227z

Posted on 1 May 2013 | 9:19 pm


Synthesis of New Quinolinequinone Derivatives and Preliminary Exploration of their Cytotoxic Properties

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Journal of Medicinal Chemistry
DOI: 10.1021/jm301689x

Posted on 1 May 2013 | 4:15 pm


Discovery of Innovative Therapeutics: Today’s Realities and Tomorrow’s Vision. 1. Criticisms Faced by the Pharmaceutical Industry

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400330j

Posted on 29 April 2013 | 10:18 pm


Quinoline Drug–Heme Interactions and Implications for Antimalarial Cytostatic versus Cytocidal Activities

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400282d

Posted on 29 April 2013 | 6:09 am


Targeting Mutant KRAS for Anticancer Therapeutics: A Review of Novel Small Molecule Modulators

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Journal of Medicinal Chemistry
DOI: 10.1021/jm3017706

Posted on 23 April 2013 | 2:33 pm


Hepatitis C Replication Inhibitors That Target the Viral NS4B Protein

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400125h

Posted on 19 April 2013 | 9:28 pm


HCV NS5A Replication Complex Inhibitors. Part 4. Optimization for Genotype 1a Replicon Inhibitory Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/jm301796k

Posted on 10 April 2013 | 2:50 pm


Orally Active Opioid Compounds from a Non-Poppy Source

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400143z

Posted on 8 April 2013 | 5:51 pm


Therapeutic Agents Triggering Nonapoptotic Cancer Cell Death

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400136m

Posted on 5 April 2013 | 10:32 pm


Structure-Based Design of ?-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease

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Journal of Medicinal Chemistry
DOI: 10.1021/jm301659n

Posted on 5 April 2013 | 7:09 pm


Discovery of Hepatitis C Virus NS3-4A Protease Inhibitors with Improved Barrier to Resistance and Favorable Liver Distribution

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Journal of Medicinal Chemistry
DOI: 10.1021/jm400121t

Posted on 28 March 2013 | 8:43 pm


Progress and Developments in Tau Aggregation Inhibitors for Alzheimer Disease

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Journal of Medicinal Chemistry
DOI: 10.1021/jm3017317

Posted on 13 March 2013 | 9:11 pm





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Chronological list of recent articles on Chemistry, Medicinal Chemistry, Journal of Medicinal Chemistry.
Update:
25.04.2011


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