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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



Peptide Inhibitors of the Escherichia coli DsbA Oxidative Machinery Essential for Bacterial Virulence

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500955s

Posted on 18 December 2014 | 5:52 pm


Iterative Conversion of Cyclin Binding Groove Peptides into Druglike CDK Inhibitors with Antitumor Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5015023

Posted on 17 December 2014 | 5:28 pm


A Conjugate Vaccine Using Enantiopure Hapten Imparts Superior Nicotine-Binding Capacity

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501625j

Posted on 17 December 2014 | 1:06 pm


Probing the Carboxyester Side Chain in Controlled Deactivation (?)-?8-Tetrahydrocannabinols

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501165d

Posted on 16 December 2014 | 7:02 pm


Conformational Analysis of the DFG-Out Kinase Motif and Biochemical Profiling of Structurally Validated Type II Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501603h

Posted on 12 December 2014 | 8:45 pm


Synthesis and Structure–Activity Relationship Studies of Small Molecule Disruptors of EWS-FLI1 Interactions in Ewing’s Sarcoma

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501372p

Posted on 12 December 2014 | 8:45 pm


Selection of Fragments for Kinase Inhibitor Design: Decoration Is Key

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501597j

Posted on 12 December 2014 | 3:21 pm


Discovery of 2-(Cyclohexylmethylamino)pyrimidines as a New Class of Reversible Valosine Containing Protein Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501313x

Posted on 12 December 2014 | 12:18 pm


Synthesis and ?-Opioid Receptor Activity of Furan-Substituted Salvinorin A Analogues

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501521d

Posted on 9 December 2014 | 9:15 pm


Discovery of Cytotoxic Dolastatin 10 Analogues with N-Terminal Modifications

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501649k

Posted on 9 December 2014 | 7:48 pm


Advancing the Kinase Field: New Targets and Second Generation Inhibitors

Journal of Medicinal Chemistry
DOI: 10.1021/jm5018708

Posted on 9 December 2014 | 5:01 pm


Synthesis, Antitumor Activity, and Mechanism of Action of Benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one Analogs of Acronycine

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500927d

Posted on 9 December 2014 | 3:44 pm


Synthesis of Gallinamide A Analogues as Potent Falcipain Inhibitors and Antimalarials

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501439w

Posted on 8 December 2014 | 8:18 pm


Inhibitors of c-Jun N-Terminal Kinases: An Update

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501212r

Posted on 8 December 2014 | 8:17 pm


Synthesis and Biological Evaluation of Pentacyclic Strychnos Alkaloids as Selective Modulators of the ABCC10 (MRP7) Efflux Pump

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501189p

Posted on 8 December 2014 | 8:15 pm


Discovery of a Phosphodiesterase 9A Inhibitor as a Potential Hypoglycemic Agent

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500836h

Posted on 8 December 2014 | 8:13 pm


Antiadhesive Properties of Glycoclusters against Pseudomonas aeruginosa Lung Infection

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500038p

Posted on 8 December 2014 | 12:18 pm


Novel Insights into Structure and Function of Factor XIIIa-Inhibitor Tridegin

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501058g

Posted on 5 December 2014 | 7:50 pm


Targeting DNA Methylation with Small Molecules: What’s Next?

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500843d

Posted on 4 December 2014 | 8:50 pm


Electrophilic Warhead-Based Design of Compounds Preventing NLRP3 Inflammasome-Dependent Pyroptosis

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501072b

Posted on 4 December 2014 | 7:56 pm


Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2–p53 Interaction

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501550p

Posted on 4 December 2014 | 2:01 pm


Parallel Worlds of Public and Commercial Bioactive Chemistry Data

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5011308

Posted on 4 December 2014 | 6:35 am


Inhibitors of p21-Activated Kinases (PAKs)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501613q

Posted on 3 December 2014 | 10:10 pm


Internalization and Stability of a Thymidylate Synthase Peptide Inhibitor in Ovarian Cancer Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501397h

Posted on 3 December 2014 | 5:26 pm


Selective Inhibitors of Protein Methyltransferases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501234a

Posted on 2 December 2014 | 6:22 am


SAR156497, an Exquisitely Selective Inhibitor of Aurora Kinases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501326k

Posted on 24 November 2014 | 7:22 pm


Targeting Aldose Reductase for the Treatment of Diabetes Complications and Inflammatory Diseases: New Insights and Future Directions

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500907a

Posted on 17 November 2014 | 8:47 pm


Inhibiting the Deubiquitinating Enzymes (DUBs)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501061a

Posted on 14 November 2014 | 8:13 pm


Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501092z

Posted on 14 November 2014 | 8:12 pm


Development of Organometallic S6K1 Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5011868

Posted on 13 November 2014 | 5:47 pm


Glucagon-like Peptide-1 (GLP-1) Analogs: Recent Advances, New Possibilities, and Therapeutic Implications

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500810s

Posted on 13 November 2014 | 12:22 pm


A New Class of Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501147g

Posted on 5 November 2014 | 12:55 pm


Recent Advances in the Development of Acetyl-CoA Carboxylase (ACC) Inhibitors for the Treatment of Metabolic Disease

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500695e

Posted on 3 November 2014 | 10:03 pm


FPR2/ALXR Agonists and the Resolution of Inflammation

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501051x

Posted on 3 November 2014 | 6:10 am


Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5013984

Posted on 23 October 2014 | 10:52 pm


Oligonucleotide Analogues as Modulators of the Expression and Function of Noncoding RNAs (ncRNAs): Emerging Therapeutics Applications

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5006594

Posted on 21 October 2014 | 8:26 pm


Targeting Matrix Metalloproteinases: Exploring the Dynamics of the S1? Pocket in the Design of Selective, Small Molecule Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500505f

Posted on 10 October 2014 | 7:30 am


Optimized Protein Kinase C? (PKC?) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5013006

Posted on 9 October 2014 | 10:29 pm


Discovery and Characterization of MAPK-activated Protein Kinase-2 Prevention of Activation Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501038s

Posted on 9 October 2014 | 10:27 pm


Exploring the Scaffold Universe of Kinase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501237k

Posted on 16 September 2014 | 5:24 pm


Small Molecule Adenosine 5?-Monophosphate Activated Protein Kinase (AMPK) Modulators and Human Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401994c

Posted on 28 August 2014 | 10:44 pm


Current Compound Coverage of the Kinome

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5008159

Posted on 30 July 2014 | 9:49 pm


Optimization of Potent DFG-in Inhibitors of Platelet Derived Growth Factor Receptor? (PDGF-R?) Guided by Water Thermodynamics

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500373x

Posted on 21 July 2014 | 10:06 pm


Development of First Lead Structures for Phosphoinositide 3-Kinase-C2? Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5006034

Posted on 14 July 2014 | 4:00 pm


Discovery of Selective and Orally Bioavailable Protein Kinase C? (PKC?) Inhibitors from a Fragment Hit

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500669m

Posted on 7 July 2014 | 11:10 pm


Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase ?

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500362j

Posted on 2 May 2014 | 1:44 pm





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Chronological list of recent articles on Chemistry, Medicinal Chemistry, Journal of Medicinal Chemistry.
Update:
28.09.2013


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