Journal of Medicinal Chemistry

Current research reports and chronological list of recent articles.


The international scientific Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

The publisher is the American Chemical Society, ACS. The copyright and publishing rights of specialized products listed below are in this publishing house. This is also responsible for the content shown.

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Additional research articles see Current Chemistry Research Articles. Magazines with similar content (medicinal chemistry):

 - Bioorganic and Medicinal Chemistry Letters,

 - European Journal of Medicinal Chemistry.

 - Journal of Enzyme Inhibition and Medicinal Chemistry,

 - Medicinal Chemistry Research,



Journal of Medicinal Chemistry - Abstracts



β-Lactamases: Why and How

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00448

Datum: 27.05.2016


Carbon Nanotubes in Biomedical Applications: Factors, Mechanisms, and Remedies of Toxicity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01770

Datum: 27.05.2016


Amphipathicity Determines Different Cytotoxic Mechanisms of Lysine- or Arginine-Rich Cationic Hydrophobic Peptides in Cancer Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b02016

Datum: 26.05.2016


Synthesis, Radiolabeling, and Biological Evaluation of 5-Hydroxy-2-[18F]fluoroalkyl-tryptophan Analogues as Potential PET Radiotracers for Tumor Imaging

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00057

Datum: 26.05.2016


Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00027

Datum: 26.05.2016


Targeted Nanoparticles for the Delivery of Novel Bioactive Molecules to Pancreatic Cancer Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01571

Datum: 26.05.2016


Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00236

Datum: 24.05.2016


Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00579

Datum: 24.05.2016


Synthesis and Biological Evaluation of 4-Anilino-quinazolines and -quinolines as Inhibitors of Breast Cancer Resistance Protein (ABCG2)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00330

Datum: 24.05.2016


Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00638

Datum: 24.05.2016


Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00215

Datum: 24.05.2016


Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00029

Datum: 24.05.2016


Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00021

Datum: 23.05.2016


Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01938

Datum: 23.05.2016


An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00443

Datum: 23.05.2016


Rigidity versus Flexibility: Is This an Issue in σ1 Receptor Ligand Affinity and Activity?

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00585

Datum: 23.05.2016


Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00275

Datum: 21.05.2016


Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00660

Datum: 20.05.2016


Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00212

Datum: 20.05.2016


Inducing Protein Degradation as a Therapeutic Strategy

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00735

Datum: 20.05.2016


Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00071

Datum: 20.05.2016


Near-Infrared Illumination of Native Tissues for Image-Guided Surgery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00038

Datum: 19.05.2016


Passive Membrane Permeability of Macrocycles Can Be Controlled by Exocyclic Amide Bonds

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00222

Datum: 19.05.2016


Rational Design of Calpain Inhibitors Based on Calpastatin Peptidomimetics

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00267

Datum: 18.05.2016


Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00483

Datum: 18.05.2016


Design Principles for Fragment Libraries: Maximizing the Value of Learnings from Pharma Fragment-Based Drug Discovery (FBDD) Programs for Use in Academia

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00197

Datum: 16.05.2016


Challenges and Opportunities for the Application of Boron Clusters in Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01932

Datum: 10.05.2016


From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer’s Disease?

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00151

Datum: 06.05.2016


Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00002

Datum: 26.04.2016


Polymerase Acidic Protein–Basic Protein 1 (PA–PB1) Protein–Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01474

Datum: 19.04.2016


Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01516

Datum: 18.04.2016


Artemisinin-Derived Dimers: Potent Antimalarial and Anticancer Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01380

Datum: 06.04.2016


Gamma Secretase Modulators: New Alzheimer’s Drugs on the Horizon?

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01960

Datum: 05.04.2016


Ten Years of Medicinal Chemistry (2005–2014) in the Journal of Medicinal Chemistry: Country of Contributors, Topics, and Public–Private Partnerships

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01349

Datum: 05.04.2016


Integrating Everything: The Molecule Selection Toolkit, a System for Compound Prioritization in Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01338

Datum: 22.03.2016


PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01813

Datum: 18.03.2016


Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01499

Datum: 14.03.2016


Targeting the Bacterial Division Protein FtsZ

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01098

Datum: 10.03.2016


An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01461

Datum: 29.02.2016


Recent Progress on Bile Acid Receptor Modulators for Treatment of Metabolic Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00342

Datum: 29.02.2016


Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00840

Datum: 26.02.2016


Chemical Space of DNA-Encoded Libraries

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01874

Datum: 25.02.2016


Design and Development of Microsomal Prostaglandin E2 Synthase-1 Inhibitors: Challenges and Future Directions

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01750

Datum: 24.02.2016


Lanthanides: Applications in Cancer Diagnosis and Therapy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01975

Datum: 19.02.2016


Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01698

Datum: 18.02.2016


Quadruplex Nucleic Acids as Novel Therapeutic Targets

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01835

Datum: 16.02.2016


Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90–Kinase Interactions

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01106

Datum: 16.02.2016


Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01485

Datum: 09.02.2016


The Medicinal Chemistry of Dengue Virus

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01653

Datum: 05.02.2016


Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01599

Datum: 28.01.2016


Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01697

Datum: 22.01.2016


Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure–Function Perspective

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01281

Datum: 19.01.2016


Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K+ Channel 1). A Novel Therapeutic Target?

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00671

Datum: 14.12.2015


Protein-Observed Fluorine NMR: A Bioorthogonal Approach for Small Molecule Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01447

Datum: 14.12.2015






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