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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500850y

Posted on 20 October 2014 | 6:29 am


Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501174m

Posted on 17 October 2014 | 6:03 am


Design, Synthesis, and Antibacterial Properties of Dual-Ligand Inhibitors of Acetyl-CoA Carboxylase

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501082n

Posted on 15 October 2014 | 7:48 pm


Design, Synthesis, Structure–Function Relationship, Bioconversion, and Pharmacokinetic Evaluation of Ertapenem Prodrugs

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500879a

Posted on 14 October 2014 | 2:40 pm


Diversity-Oriented Synthesis-Facilitated Medicinal Chemistry: Toward the Development of Novel Antimalarial Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500994n

Posted on 13 October 2014 | 9:21 pm


Potent Nonimmunosuppressive Cyclophilin Inhibitors With Improved Pharmaceutical Properties and Decreased Transporter Inhibition

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500862r

Posted on 13 October 2014 | 9:20 pm


C-Glycoside Mimetics Inhibit Glioma Stem Cell Proliferation, Migration, and Invasion

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500522y

Posted on 10 October 2014 | 3:19 pm


Oligo-?-(1 ? 3)-glucans: Impact of Thio-Bridges on Immunostimulating Activities and the Development of Cancer Stem Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500506b

Posted on 10 October 2014 | 12:33 pm


Targeting Matrix Metalloproteinases: Exploring the Dynamics of the S1? Pocket in the Design of Selective, Small Molecule Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500505f

Posted on 10 October 2014 | 6:30 am


Optimized Protein Kinase C? (PKC?) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5013006

Posted on 9 October 2014 | 9:29 pm


Discovery and Characterization of MAPK-activated Protein Kinase-2 Prevention of Activation Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501038s

Posted on 9 October 2014 | 9:27 pm


Potent Heterocyclic Ligands for Human Complement C3a Receptor

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500956p

Posted on 8 October 2014 | 10:28 pm


Modulation of cAMP-Specific PDE without Emetogenic Activity: New Sulfide-Like PDE7 Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501090m

Posted on 8 October 2014 | 10:02 pm


ST7612AA1, a Thioacetate-?(?-lactam carboxamide) Derivative Selected from a Novel Generation of Oral HDAC Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5008209

Posted on 8 October 2014 | 5:18 pm


Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500734a

Posted on 8 October 2014 | 5:04 pm


Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500497v

Posted on 8 October 2014 | 5:04 pm


Structural Insights into Carbonic Anhydrase IX Isoform Specificity of Carbohydrate-Based Sulfamates

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5012935

Posted on 8 October 2014 | 4:52 pm


Discovery of N-Substituted Oseltamivir Derivatives as Potent and Selective Inhibitors of H5N1 Influenza Neuraminidase

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500892k

Posted on 8 October 2014 | 4:30 pm


Development of Novel Neurokinin 3 Receptor (NK3R) Selective Agonists with Resistance to Proteolytic Degradation

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500771w

Posted on 7 October 2014 | 5:52 pm


Repurposing the Antihistamine Terfenadine for Antimicrobial Activity against Staphylococcus aureus

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5010682

Posted on 6 October 2014 | 10:25 pm


Beyond C, H, O, and N! Analysis of the Elemental Composition of U.S. FDA Approved Drug Architectures

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501105n

Posted on 6 October 2014 | 7:27 pm


Synthesis and Biological Activity of 25-Hydroxy-2-methylene-vitamin D3 Analogues Monohydroxylated in the A-ring

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500750b

Posted on 2 October 2014 | 7:49 pm


Discovery of Potent and Selective Sirtuin 2 (SIRT2) Inhibitors Using a Fragment-Based Approach

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500777s

Posted on 2 October 2014 | 4:27 pm


Selenorhodamine Photosensitizers for Photodynamic Therapy of P-Glycoprotein-Expressing Cancer Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501259v

Posted on 1 October 2014 | 9:33 pm


Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5011397

Posted on 1 October 2014 | 5:35 pm


Tumor Xenograft Uptake of a Pyrrole–Imidazole (Py-Im) Polyamide Varies as a Function of Cell Line Grafted

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500964c

Posted on 1 October 2014 | 5:35 pm


Cyclic Adenosine 5?-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase–Hydrolase CD38

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501037u

Posted on 1 October 2014 | 2:02 pm


Development of Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5010978

Posted on 25 September 2014 | 2:48 pm


Peptides Containing ?-Amino Acid Patterns: Challenges and Successes in Medicinal Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5010896

Posted on 24 September 2014 | 3:38 pm


Acidic and Basic Drugs in Medicinal Chemistry: A Perspective

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501000a

Posted on 18 September 2014 | 4:30 pm


Exploring the Scaffold Universe of Kinase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501237k

Posted on 16 September 2014 | 4:24 pm


Positron Emission Tomography in CNS Drug Discovery and Drug Monitoring

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5001858

Posted on 10 September 2014 | 9:42 pm


Natural Products in Medicine: Transformational Outcome of Synthetic Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500941m

Posted on 10 September 2014 | 8:46 pm


Desferrithiocin: A Search for Clinically Effective Iron Chelators

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500828f

Posted on 10 September 2014 | 8:46 pm


Medicinal Chemistry of Catechol O-Methyltransferase (COMT) Inhibitors and Their Therapeutic Utility

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500572b

Posted on 2 September 2014 | 11:08 pm


Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500823a

Posted on 29 August 2014 | 6:37 am


Small Molecule Adenosine 5?-Monophosphate Activated Protein Kinase (AMPK) Modulators and Human Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401994c

Posted on 28 August 2014 | 9:44 pm


Rational Use of Plasma Protein and Tissue Binding Data in Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5007935

Posted on 6 August 2014 | 7:51 pm


Small Molecule Ghrelin Receptor Inverse Agonists and Antagonists

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5003183

Posted on 6 August 2014 | 2:20 pm


Current Compound Coverage of the Kinome

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5008159

Posted on 30 July 2014 | 8:49 pm


Optimization of Potent DFG-in Inhibitors of Platelet Derived Growth Factor Receptor? (PDGF-R?) Guided by Water Thermodynamics

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500373x

Posted on 21 July 2014 | 9:06 pm


Development of First Lead Structures for Phosphoinositide 3-Kinase-C2? Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5006034

Posted on 14 July 2014 | 3:00 pm


Toward Fluorescent Probes for G-Protein-Coupled Receptors (GPCRs)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401823z

Posted on 10 July 2014 | 9:01 pm


Targeting the Androgen Receptor with Steroid Conjugates

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500101h

Posted on 8 July 2014 | 6:35 am


Discovery of Selective and Orally Bioavailable Protein Kinase C? (PKC?) Inhibitors from a Fragment Hit

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500669m

Posted on 7 July 2014 | 10:10 pm


Recent Developments in Novel Antidepressants Targeting ?4?2-Nicotinic Acetylcholine Receptors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401937a

Posted on 2 July 2014 | 10:11 pm


Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase ?

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500362j

Posted on 2 May 2014 | 12:44 pm





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Chronological list of recent articles on Chemistry, Medicinal Chemistry, Journal of Medicinal Chemistry.
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28.09.2013


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