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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00495

Posted on 31 August 2015 | 10:20 pm


Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01082

Posted on 31 August 2015 | 3:33 pm


A Journey around the Medicinal Chemistry of Hepatitis C Virus Inhibitors Targeting NS4B: From Target to Preclinical Drug Candidates

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00825

Posted on 31 August 2015 | 3:31 pm


Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00999

Posted on 31 August 2015 | 1:04 pm


6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00438

Posted on 30 August 2015 | 2:00 pm


An Aggregation Advisor for Ligand Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01105

Posted on 28 August 2015 | 10:07 pm


Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00709

Posted on 28 August 2015 | 10:00 pm


N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00367

Posted on 28 August 2015 | 5:13 pm


Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00585

Posted on 28 August 2015 | 5:12 pm


Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00545

Posted on 27 August 2015 | 7:44 pm


Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00988

Posted on 26 August 2015 | 3:16 pm


Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00746

Posted on 26 August 2015 | 3:16 pm


Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00684

Posted on 26 August 2015 | 3:12 pm


Highly Sensitive Near-Infrared Fluorophores for in Vivo Detection of Amyloid-? Plaques in Alzheimer’s Disease

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00861

Posted on 25 August 2015 | 5:52 pm


Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00992

Posted on 24 August 2015 | 6:59 am


Fragment Binding Can Be Either More Enthalpy-Driven or Entropy-Driven: Crystal Structures and Residual Hydration Patterns Suggest Why

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00812

Posted on 24 August 2015 | 6:39 am


Quantifying, Visualizing, and Monitoring Lead Optimization

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00948

Posted on 21 August 2015 | 1:12 pm


Syntheses and Biological Evaluation of Costunolide, Parthenolide, and Their Fluorinated Analogues

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00915

Posted on 20 August 2015 | 9:45 pm


Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01011

Posted on 20 August 2015 | 1:24 pm


Recent Advances in the Discovery of Norovirus Therapeutics

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00762

Posted on 17 August 2015 | 10:17 pm


Sortase A Inhibitors: Recent Advances and Future Perspectives

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00779

Posted on 17 August 2015 | 7:14 pm


Discovery of Potent and Selective RSK Inhibitors as Biological Probes

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00450

Posted on 13 August 2015 | 9:57 pm


New Frontiers in Druggability

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00586

Posted on 11 August 2015 | 6:40 am


Hydroxytyrosol-Derived Compounds: A Basis for the Creation of New Pharmacological Agents for Cancer Prevention and Therapy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00669

Posted on 7 August 2015 | 8:54 pm


Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00461

Posted on 5 August 2015 | 7:42 pm


Applications of Fluorine in Medicinal Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00258

Posted on 22 July 2015 | 8:34 pm


Development of Safe and Effective Botanical Dietary Supplements

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00417

Posted on 21 July 2015 | 4:02 pm


Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00171

Posted on 15 July 2015 | 5:51 pm


Fragment-Based Design of Selective Nanomolar Ligands of the CREBBP Bromodomain

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00172

Posted on 15 July 2015 | 5:51 pm


DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00150

Posted on 10 July 2015 | 10:14 pm


Regulation of the Apelinergic System and Its Potential in Cardiovascular Disease: Peptides and Small Molecules as Tools for Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00527

Posted on 10 July 2015 | 4:11 pm


Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00405

Posted on 6 July 2015 | 6:02 am


The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00313

Posted on 2 July 2015 | 10:34 pm


Therapeutic Potential of 5-HT6 Receptor Agonists

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00179

Posted on 2 July 2015 | 6:49 am


Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00229

Posted on 1 July 2015 | 8:05 pm


Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women’s Health

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00386

Posted on 12 June 2015 | 3:52 pm


Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00516

Posted on 3 June 2015 | 3:59 pm


Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00326

Posted on 26 May 2015 | 8:39 pm


Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00458

Posted on 20 May 2015 | 8:45 pm


Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501981g

Posted on 14 May 2015 | 8:28 pm


Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00261

Posted on 14 May 2015 | 7:10 pm


New Frontiers in Selective Human MAO-B Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501690r

Posted on 11 May 2015 | 6:53 am


Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00256

Posted on 30 April 2015 | 2:00 pm


Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b00209

Posted on 6 April 2015 | 2:30 pm





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