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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



Identification of a Novel Aminotetralin Class of HDAC6 and HDAC8 Selective Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5008962

Posted on 30 September 2014 | 9:16 pm


Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500958x

Posted on 29 September 2014 | 9:27 pm


Synthesis and Biological Evaluation of Novel Millepachine Derivatives As a New Class of Tubulin Polymerization Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500849z

Posted on 29 September 2014 | 8:31 pm


Discovery, Biological Evaluation, and Crystal Structure of a Novel Nanomolar Selective Butyrylcholinesterase Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501195e

Posted on 29 September 2014 | 2:37 pm


Development of Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5010978

Posted on 25 September 2014 | 2:48 pm


Blood Schizontocidal and Gametocytocidal Activity of 3-Hydroxy-N?-arylidenepropanehydrazonamides: A New Class of Antiplasmodial Compounds

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500811p

Posted on 25 September 2014 | 2:46 pm


Development of ?GlcN(1?1)?Man-Based Lipid A Mimetics as a Novel Class of Potent Toll-like Receptor 4 Agonists

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500946r

Posted on 25 September 2014 | 1:37 pm


Peptides Containing ?-Amino Acid Patterns: Challenges and Successes in Medicinal Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5010896

Posted on 24 September 2014 | 3:38 pm


The Discovery of I-BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5010539

Posted on 24 September 2014 | 12:53 pm


Synthesis and Molecular Recognition Studies on Small-Molecule Inhibitors for Thioredoxin Reductase

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5012098

Posted on 24 September 2014 | 12:52 pm


Thioaryl Naphthylmethanone Oxime Ether Analogs as Novel Anticancer Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500873e

Posted on 22 September 2014 | 6:08 am


In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500872p

Posted on 18 September 2014 | 9:55 pm


Acidic and Basic Drugs in Medicinal Chemistry: A Perspective

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501000a

Posted on 18 September 2014 | 4:30 pm


Tailor-Made Fluorescent Trilobolide To Study Its Biological Relevance

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500690j

Posted on 17 September 2014 | 9:28 pm


Discovery of 2-Pyridylureas as Glucokinase Activators

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501204z

Posted on 17 September 2014 | 9:27 pm


Exploring the Scaffold Universe of Kinase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm501237k

Posted on 16 September 2014 | 4:24 pm


Developing Second Generation Antibody–Drug Conjugates: The Quest for New Technologies

Journal of Medicinal Chemistry
DOI: 10.1021/jm501298k

Posted on 15 September 2014 | 12:52 pm


Positron Emission Tomography in CNS Drug Discovery and Drug Monitoring

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5001858

Posted on 10 September 2014 | 9:42 pm


Natural Products in Medicine: Transformational Outcome of Synthetic Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500941m

Posted on 10 September 2014 | 8:46 pm


Desferrithiocin: A Search for Clinically Effective Iron Chelators

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500828f

Posted on 10 September 2014 | 8:46 pm


Medicinal Chemistry of Catechol O-Methyltransferase (COMT) Inhibitors and Their Therapeutic Utility

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500572b

Posted on 2 September 2014 | 11:08 pm


Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500823a

Posted on 29 August 2014 | 6:37 am


Small Molecule Adenosine 5?-Monophosphate Activated Protein Kinase (AMPK) Modulators and Human Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401994c

Posted on 28 August 2014 | 9:44 pm


Rational Use of Plasma Protein and Tissue Binding Data in Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5007935

Posted on 6 August 2014 | 7:51 pm


Small Molecule Ghrelin Receptor Inverse Agonists and Antagonists

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5003183

Posted on 6 August 2014 | 2:20 pm


Current Compound Coverage of the Kinome

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5008159

Posted on 30 July 2014 | 8:49 pm


Optimization of Potent DFG-in Inhibitors of Platelet Derived Growth Factor Receptor? (PDGF-R?) Guided by Water Thermodynamics

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500373x

Posted on 21 July 2014 | 9:06 pm


Development of First Lead Structures for Phosphoinositide 3-Kinase-C2? Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5006034

Posted on 14 July 2014 | 3:00 pm


Toward Fluorescent Probes for G-Protein-Coupled Receptors (GPCRs)

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401823z

Posted on 10 July 2014 | 9:01 pm


Targeting the Androgen Receptor with Steroid Conjugates

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500101h

Posted on 8 July 2014 | 6:35 am


Discovery of Selective and Orally Bioavailable Protein Kinase C? (PKC?) Inhibitors from a Fragment Hit

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500669m

Posted on 7 July 2014 | 10:10 pm


Recent Developments in Novel Antidepressants Targeting ?4?2-Nicotinic Acetylcholine Receptors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm401937a

Posted on 2 July 2014 | 10:11 pm


Polypharmacology: Challenges and Opportunities in Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/jm5006463

Posted on 25 June 2014 | 10:27 pm


Calcitonin Gene-Related Peptide Receptor Antagonists: New Therapeutic Agents for Migraine

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500364u

Posted on 24 June 2014 | 10:26 pm


Development of Synthetic Lethality Anticancer Therapeutics

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500415t

Posted on 13 June 2014 | 8:52 pm


Elements and Modulation of Functional Dynamics

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500325k

Posted on 10 June 2014 | 2:08 pm


Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase ?

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Journal of Medicinal Chemistry
DOI: 10.1021/jm500362j

Posted on 2 May 2014 | 12:44 pm





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Chronological list of recent articles on Chemistry, Medicinal Chemistry, Journal of Medicinal Chemistry.
Update:
28.09.2013


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