Journal of Medicinal Chemistry

Current research reports and chronological list of recent articles.


The international scientific Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

The publisher is the American Chemical Society, ACS. The copyright and publishing rights of specialized products listed below are in this publishing house. This is also responsible for the content shown.

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Additional research articles see Current Chemistry Research Articles. Magazines with similar content (medicinal chemistry):

 - Bioorganic and Medicinal Chemistry Letters,

 - European Journal of Medicinal Chemistry.

 - Journal of Enzyme Inhibition and Medicinal Chemistry,

 - Medicinal Chemistry Research,



Journal of Medicinal Chemistry - Abstracts



Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00070

Datum: 24.08.2016


Synthesis and Antileukemic Activities of Piperlongumine and HDAC Inhibitor Hybrids against Acute Myeloid Leukemia Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00772

Datum: 24.08.2016


Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00041

Datum: 23.08.2016


Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00554

Datum: 23.08.2016


Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00747

Datum: 23.08.2016


A Selective Galactose–Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00957

Datum: 23.08.2016


1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00986

Datum: 22.08.2016


Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b01157

Datum: 22.08.2016


Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00883

Datum: 22.08.2016


Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00866

Datum: 20.08.2016


Human Toll-like Receptor (TLR) 8-Specific Agonistic Activity in Substituted Pyrimidine-2,4-diamines

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00872

Datum: 19.08.2016


Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00793

Datum: 19.08.2016


Optimization of Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for Duration of Action, as an Inhaled Therapy for Lung Remodeling in Pulmonary Arterial Hypertension

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00703

Datum: 19.08.2016


Synthesis, Antibacterial, and Anticancer Evaluation of Novel Spiramycin-Like Conjugates Containing C(5) Triazole Arm

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00764

Datum: 19.08.2016


Allosteric Modulation of Phosphatase Activity May Redefine Therapeutic Value

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b01210

Datum: 19.08.2016


Identification and Investigation of Novel Binding Fragments in the Fatty Acid Binding Protein 6 (FABP6)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00869

Datum: 18.08.2016


Driving Structure-Based Drug Discovery through Cosolvent Molecular Dynamics

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00399

Datum: 17.08.2016


Small Molecules in Development for the Treatment of Spinal Muscular Atrophy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00670

Datum: 16.08.2016


Small Molecule Kinase Inhibitors for the Treatment of Brain Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00618

Datum: 03.08.2016


Drug-like Antagonists of P2Y ReceptorsFrom Lead Identification to Drug Development

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01972

Datum: 01.08.2016


Transient Receptor Potential Melastatin 8 Channel (TRPM8) Modulation: Cool Entryway for Treating Pain and Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00305

Datum: 01.08.2016


Therapeutic Potential of Foldamers: From Chemical Biology Tools To Drug Candidates?

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00376

Datum: 29.07.2016


The Medicinal Chemistry of Therapeutic Oligonucleotides

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00551

Datum: 29.07.2016


An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00055

Datum: 27.07.2016


Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00411

Datum: 25.07.2016


Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00596

Datum: 19.07.2016


Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00680

Datum: 12.07.2016


Underexplored Opportunities for Natural Products in Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00473

Datum: 11.07.2016


G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01939

Datum: 08.07.2016


The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00472

Datum: 30.06.2016


Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00463

Datum: 27.06.2016


Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01335

Datum: 27.06.2016


Endothelin-Receptor Antagonists beyond Pulmonary Arterial Hypertension: Cancer and Fibrosis

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01781

Datum: 15.06.2016


Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00150

Datum: 03.06.2016


β-Lactamases: Why and How

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00448

Datum: 27.05.2016


Carbon Nanotubes in Biomedical Applications: Factors, Mechanisms, and Remedies of Toxicity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01770

Datum: 27.05.2016


Design Principles for Fragment Libraries: Maximizing the Value of Learnings from Pharma Fragment-Based Drug Discovery (FBDD) Programs for Use in Academia

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00197

Datum: 16.05.2016


Challenges and Opportunities for the Application of Boron Clusters in Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01932

Datum: 10.05.2016


From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer’s Disease?

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00151

Datum: 06.05.2016


Polymerase Acidic Protein–Basic Protein 1 (PA–PB1) Protein–Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01474

Datum: 19.04.2016


Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5b01516

Datum: 18.04.2016






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