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Retrosynthesis

The retrosynthetic analysis.




Retrosynthesis or retrosynthetic analysis is a strategy for planning an organic synthesis by disconnecting a target molecule into precursor materials. This steps are repeated until available starting materials are reached.

The retrosynthetic analysis is not a synthesis form of organic chemistry, but an analytical approach based on the desired product. The target molecule is broken down into smaller and smaller fragments. The actual synthesis can then be designed based on the retrosynthetic analysis.

The method of retrosynthetic analysis is very effective, but it requires a great knowledge of chemical compounds, classes of compounds, chemical reactions, reaction conditions etc.

Below you will find online available information resources on retrosynthesis and retrosynthetic analysis.



Content, Topics


Current Articles
Lecture Notes, Tutorials
Partial Information
Compounds



Current Articles


Aide de L'Ordinatuer en Synthese Organique
R. Barone, Cycle Chimie Fine, juin 2001 - [f]

Retrosynthesis Tutorial
... will allow you to practice retrosynthetic analysis using the target molecule below. You will find that there are several different ways to complete the retrosynthesis, depending on which strategies you choose. University of East Anglia, UK

Retrosynthetic Analysis
Analysis of Complex Synthetic Problems; Terminology; Retrosynthetic Strategies; Goals and Subgoals; Computer-Assisted Retrosynthetic Analysis. CMBI



Lecture Notes, Tutorials


Advanced Retrosynthesis
Lecture notes

Disconnection Approach
Introduction to chemical synthesis - Format: PDF

Putting Reactions Together
Synthesis and Retrosynthesis. Arizona State University, USA - Format: PDF

Retrosynthesis
The synthetic route to a target molecule: definitions and terms - Format: PDF

Retrosynthesis
Tutorial: Advanced Organic Chemistry - Format: PDF

Retrosynthesis
Lecture notes: designing organic syntheses. Universität Regensburg - Format: PDF

Retrosynthesis
Notes and examples

Retrosynthesis Tutorial
Organic Synthesis and Carbon-Carbon Bond Forming Reactions

Retrosynthetic Analysis
Lecture notes - Format: PDF

Retrosynthetic Analysis
An introduction - Format: PDF

Retrosynthetic Analysis
Strategies in synthetic planning - Format: PDF

Retrosynthetic Analysis
Advanced organic chemistry tutorial - Format: PDF

Retrosynthetic Analysis
Exercises in basic disconnections - Format: PDF

Retrosynthetic Analysis
An introduction - Format: PDF

Retrosynthetic Analysis
An introduction - Format: PDF

Retrosynthetic Analysis
Strategy of synthesis - Format: PDF

Retrosynthetic Analysis and Synthetic Planning
Basics - Format: PDF

Solutions Manual
Some examples - Format: PDF

Strategies in Synthetic Planning
Modern Stylistic Points in Retrosynthetic Analysis - Format: PDF

Weighted Graphs
Retrosynthetic analysis via weighted graphs - Format: PDF



Partial Information




Compounds


2-Methyl-1-propanol
. . . from 2-bromo-2-methylpropane - Format: PDF

Antillatoxin
Retrosynthetic Analysis of Antillatoxin - Format: PDF

Momilactone
Retrosynthetic analysis of Momilactone, Seychellene, Longifolene - Format: PDF

Monensin
Retrosynthetic analysis - Format: PDF

Reserpine
Total Synthesis of (±)-Reserpine - Format: PDF

Tetrodotoxin
Survey of Tetrodotoxin Syntheses - Format: PDF

 


Last update: 02.11.2018.






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