The retrosynthetic analysis.

Retrosynthesis or retrosynthetic analysis is a strategy for planning an organic synthesis by disconnecting a target molecule into precursor materials. This steps are repeated until available starting materials are reached.

The retrosynthetic analysis is not a synthesis form of organic chemistry, but an analytical approach based on the desired product. The target molecule is broken down into smaller and smaller fragments. The actual synthesis can then be designed based on the retrosynthetic analysis.

The method of retrosynthetic analysis is very effective, but it requires a great knowledge of chemical compounds, classes of compounds, chemical reactions, reaction conditions etc.

Below you will find online available information resources on retrosynthesis and retrosynthetic analysis.


Current Articles
Lecture Notes, Tutorials
Partial Information

Current Articles

Aide de L'Ordinatuer en Synthese Organique
R. Barone, Cycle Chimie Fine, juin 2001 - [f]

Retrosynthesis Tutorial
... will allow you to practice retrosynthetic analysis using the target molecule below. You will find that there are several different ways to complete the retrosynthesis, depending on which strategies you choose. University of East Anglia, UK

Retrosynthetic Analysis
Analysis of Complex Synthetic Problems; Terminology; Retrosynthetic Strategies; Goals and Subgoals; Computer-Assisted Retrosynthetic Analysis. CMBI

Lecture Notes, Tutorials

Advanced Retrosynthesis
Lecture notes

Disconnection Approach
Introduction to chemical synthesis - Format: PDF

Putting Reactions Together
Synthesis and Retrosynthesis. Arizona State University, USA - Format: PDF

Definitions and terms - Format: PDF

Tutorial: Advanced Organic Chemistry - Format: PDF

Lecture notes: designing organic syntheses. Universität Regensburg - Format: PDF

Notes and examples

Retrosynthesis Tutorial
Organic Synthesis and Carbon-Carbon Bond Forming Reactions

Retrosynthetic Analysis
Lecture notes - Format: PDF

Retrosynthetic Analysis
An introduction - Format: PDF

Retrosynthetic Analysis
Strategies in synthetic planning - Format: PDF

Retrosynthetic Analysis
The synthetic route to a target molecule - Format: PDF

Retrosynthetic Analysis
Exercises in basic disconnections - Format: PDF

Retrosynthetic Analysis
An introduction - Format: PDF

Retrosynthetic Analysis
An introduction - Format: PDF

Retrosynthetic Analysis
Strategy of synthesis - Format: PDF

Retrosynthetic Analysis and Synthetic Planning
Basics - Format: PDF

Solutions Manual
Some examples - Format: PDF

Strategies in Synthetic Planning
Modern Stylistic Points in Retrosynthetic Analysis - Format: PDF

Weighted Graphs
Retrosynthetic analysis via weighted graphs - Format: PDF

Partial Information

Diels-Alder Retrosynthesis


. . . from 2-bromo-2-methylpropane - Format: PDF

Retrosynthetic Analysis of Antillatoxin - Format: PDF

Retrosynthetic analysis of Momilactone, Seychellene, Longifolene - Format: PDF

Retrosynthetic analysis - Format: PDF

Total Synthesis of (±)-Reserpine - Format: PDF

Survey of Tetrodotoxin Syntheses - Format: PDF

Related Books and Scientific Literature: Retrosynthesis

Book recommendation

Paul Wyatt, Stuart Warren

Organic Synthesis: Strategy and Control

Organic Synthesis: Strategy and Control is a sequel to Stuart Warren’s bestseller Organic Synthesis: The Disconnection Approach. The ‘Disconnection’ book concentrated on the planning behind the synthesis of compounds.

The two themes of this new book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work.

The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. Interpenetrating this structure, the 36 chapters start with classic methods and progress to modern methods and modern strategic considerations. Heterocyclic chemistry is treated throughout the book with full mechanistic explanations as part of organic chemistry rather than a separate mystery.

Wiley; 2007

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Last update 16.11.2016

Keywords: Retrosynthesis, basics, information, theory, methods

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